Lapatinib In Combination With Trastuzumab Versus Lapatinib Monotherapy In Subjects With HER2-positive Metastatic Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

296

Participants

Timeline

Start Date

November 30, 2005

Primary Completion Date

June 30, 2007

Study Completion Date

October 31, 2010

Conditions
Neoplasms, Breast
Interventions
DRUG

Lapatinib

oral lapatinib once daily

BIOLOGICAL

Trastuzumab

IV trastuzumab 2mg/kg weekly after 4mg/kg loading dose

Trial Locations (145)

1572

GSK Investigational Site, Sofia

4000

GSK Investigational Site, Plovdiv

10016

GSK Investigational Site, New York

10367

GSK Investigational Site, Berlin

12200

GSK Investigational Site, Berlin

12208

GSK Investigational Site, Albany

13122

GSK Investigational Site, Athens

15213

GSK Investigational Site, Pittsburgh

15517

GSK Investigational Site, Fürstenwalde

17033

GSK Investigational Site, Hershey

18547

GSK Investigational Site, Neo Faliro

18704

GSK Investigational Site, Kingston

19010

GSK Investigational Site, Bryn Mawr

19104

GSK Investigational Site, Philadelphia

19611

GSK Investigational Site, West Reading

19713

GSK Investigational Site, Newark

20089

GSK Investigational Site, Rozzano (MI)

21000

GSK Investigational Site, Split

22081

GSK Investigational Site, Hamburg

22457

GSK Investigational Site, Hamburg

22767

GSK Investigational Site, Hamburg

23230

GSK Investigational Site, Richmond

23502

GSK Investigational Site, Norfolk

24103

GSK Investigational Site, Kiel

24153

GSK Investigational Site, Salem

25198

GSK Investigational Site, Lleida

26789

GSK Investigational Site, Leer

27511

GSK Investigational Site, Cary

27710

GSK Investigational Site, Durham

28041

GSK Investigational Site, Madrid

28203

GSK Investigational Site, Charlotte

28602

GSK Investigational Site, Hickory

29605

GSK Investigational Site, Greenville

32256

GSK Investigational Site, Jacksonville

32605

GSK Investigational Site, Gainesville

32804

GSK Investigational Site, Orlando

33021

GSK Investigational Site, Hollywood

33136

GSK Investigational Site, Miami

33401

GSK Investigational Site, West Palm Beach

33428

GSK Investigational Site, Boca Raton

33520

GSK Investigational Site, Tampere

33916

GSK Investigational Site, Fort Myers

34474

GSK Investigational Site, Ocala

34761

GSK Investigational Site, Ocoee

37203

GSK Investigational Site, Nashville

38320

GSK Investigational Site, Santa Cruz de Tenerife

39108

GSK Investigational Site, Magdeburg

42551

GSK Investigational Site, Velbert

44623

GSK Investigational Site, Herne

44710

GSK Investigational Site, Canton

45409

GSK Investigational Site, Kettering

46010

GSK Investigational Site, Valencia

46202

GSK Investigational Site, Indianapolis

46227

GSK Investigational Site, Indianapolis

47802

GSK Investigational Site, Terre Haute

48100

GSK Investigational Site, Ravenna

52403

GSK Investigational Site, Cedar Rapids

53840

GSK Investigational Site, Troisdorf

54301

GSK Investigational Site, Green Bay

55404

GSK Investigational Site, Minneapolis

55422

GSK Investigational Site, Robbinsdale

60596

GSK Investigational Site, Frankfurt am Main

60714

GSK Investigational Site, Niles

64507

GSK Investigational Site, Saint Joseph

65201

GSK Investigational Site, Columbia

66103

GSK Investigational Site, Kansas City

66113

GSK Investigational Site, Saarbrücken

66210

GSK Investigational Site, Overland Park

69115

GSK Investigational Site, Heidelberg

70126

GSK Investigational Site, Bari

70190

GSK Investigational Site, Stuttgart

70199

GSK Investigational Site, Stuttgart

73100

GSK Investigational Site, Lecce

73112

GSK Investigational Site, Oklahoma City

75067

GSK Investigational Site, Lewisville

75150

GSK Investigational Site, Mesquite

75230

GSK Investigational Site, Dallas

75231

GSK Investigational Site, Dallas

75237

GSK Investigational Site, Dallas

75246

GSK Investigational Site, Dallas

75460

GSK Investigational Site, Paris

75601

GSK Investigational Site, Longview

75702

GSK Investigational Site, Tyler

76014

GSK Investigational Site, Arlington

76022

GSK Investigational Site, Bedford

76104

GSK Investigational Site, Fort Worth

76210

GSK Investigational Site, Denton

76712

GSK Investigational Site, Waco

78624

GSK Investigational Site, Fredericksburg

78731

GSK Investigational Site, Austin

79701

GSK Investigational Site, Midland

79761

GSK Investigational Site, Odessa

79915

GSK Investigational Site, El Paso

80331

GSK Investigational Site, Munich

85012

GSK Investigational Site, Phoenix

86150

GSK Investigational Site, Augsburg

86336

GSK Investigational Site, Sedona

89109

GSK Investigational Site, Las Vegas

89135

GSK Investigational Site, Las Vegas

92120

GSK Investigational Site, San Diego

92346

GSK Investigational Site, Highland

94589

GSK Investigational Site, Vallejo

95819

GSK Investigational Site, Sacramento

96450

GSK Investigational Site, Coburg

98026

GSK Investigational Site, Edmonds

98133

GSK Investigational Site, Seattle

98684

GSK Investigational Site, Vancouver

98902

GSK Investigational Site, Yakima

99202

GSK Investigational Site, Spokane

94115-1710

GSK Investigational Site, San Francisco

95403-1757

GSK Investigational Site, Santa Rosa

30046-7650

GSK Investigational Site, Lawrenceville

02115

GSK Investigational Site, Boston

07042

GSK Investigational Site, Montclair

07962

GSK Investigational Site, Morristown

08901

GSK Investigational Site, New Brunswick

07901

GSK Investigational Site, Summit

08043

GSK Investigational Site, Voorhees Township

74136-1902

GSK Investigational Site, Tulsa

77702-1449

GSK Investigational Site, Beaumont

78503-1298

GSK Investigational Site, McAllen

A-5020

GSK Investigational Site, Salzburg

A-1090

GSK Investigational Site, Vienna

H7M 3L9

GSK Investigational Site, Laval

H2L 4M1

GSK Investigational Site, Montreal

H4J 1C5

GSK Investigational Site, Montreal

10 000

GSK Investigational Site, Zagreb

656 53

GSK Investigational Site, Brno

150 08

GSK Investigational Site, Prague

180 00

GSK Investigational Site, Prague

06120

GSK Investigational Site, Halle

115 22

GSK Investigational Site, Athens

185 37

GSK Investigational Site, Athens

00144

GSK Investigational Site, Rome

06156

GSK Investigational Site, Perugia

15-027

GSK Investigational Site, Bialystok

10-226

GSK Investigational Site, Olsztyn

10-228

GSK Investigational Site, Olsztyn

02-781

GSK Investigational Site, Warsaw

53-413

GSK Investigational Site, Wroclaw

08035

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, Hospitalet de Llobregat (Barcelona)

HD3 3EA

GSK Investigational Site, Huddersfield

IP4 5PD

GSK Investigational Site, Ipswich

SE1 9RT

GSK Investigational Site, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY