A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

374

Participants

Timeline

Start Date

November 30, 2005

Primary Completion Date

March 31, 2008

Study Completion Date

March 31, 2008

Conditions
Rheumatoid Arthritis
Interventions
DRUG

P38 Inhibitor (4) 150mg

150mg po qd

DRUG

P38 Inhibitor (4) 25mg

25mg po bid

DRUG

P38 Inhibitor (4) 300mg

300mg po qd

DRUG

P38 Inhibitor (4) 50mg

50mg po qd

DRUG

P38 Inhibitor (4) 75mg

75mg po bid

DRUG

Placebo

po bid

Trial Locations (114)

4

Dublin

9

Dublin

1619

Johannesburg

2025

Auckland

3065

Fitzroy

4001

Durban

4021

Kippa-Ring

4510

Caboolture

5010

Lower Hutt

7500

Cape Town

8011

Christchurch

9301

Bloemfontein

10128

Tallinn

11312

Tallinn

11521

Athens

12200

Berlin

13413

New Hartford

13419

Tallinn

14004

Córdoba

14059

Berlin

14618

Rochester

15006

A Coruña

15237

Pittsburgh

17011

Camp Hill

18711

Wilkes-Barre

23502

Norfolk

27004

Lugo

28012

Belmont

28034

Madrid

30303

Atlanta

30342

Atlanta

31210

Macon

32174

Ormond Beach

32607

Gainesville

33321

Tamarac

34232

Sarasota

34474

Ocala

35242

Birmingham

37909

Knoxville

38104

Memphis

38305

Jackson

38320

San Cristóbal de La Laguna

44620

Guadalajara

46321

Munster

46601

South Bend

49684

Traverse City

53566

Monroe

56403

Thessaloniki

57105

Sioux Falls

58122

North Fargo

61231

Bad Nauheim

64460

Monterrey

65191

Wiesbaden

67207

Wichita

68114

Omaha

71003

Heraklion

74136

Tulsa

75007

Carrollton

77802

Bryan

78240

San Luis Potosí City

79106

Amarillo

79424

Lubbock

80336

München

83687

Nampa

85253

Paradise Valley

85704

Tucson

85711

Tucson

85712

Tucson

87102

Albuquerque

91054

Erlangen

91786

Upland

92025

Escondido

92357

Loma Linda

92501

Riverside

95628

Fair Oaks

97701

Bend

98133

Seattle

98201

Everett

99096

Erfurt

01610

Worcester

08755

Toms River

80060-240

Curitiba

74043-110

Goiânia

04266-010

São Paulo

T5H 3V9

Edmonton

R3N 0K6

Winnipeg

A1A 5E8

St. John's

L5M 2V8

Mississauga

K2G 6E2

Ottawa

M4K 1N2

Toronto

M5T 2S8

Toronto

H9R 3J1

Pointe-Claire

04107

Leipzig

115 27

Athens

455 00

Ioannina

03100

Mexico City

82-300

Elblag

81-759

Sopot

71-252

Szczecin

87-100

Torun

02-256

Warsaw

02-637

Warsaw

0002

Pretoria

08003

Barcelona

08035

Barcelona

08208

Sabadell

RG24 9NA

Basingstoke

WS11 5XY

Cannock

HG2 7SX

Harrogate

LS7 4SA

Leeds

CH49 5PE

Metropolitan Borough of Wirral

NE1 4LP

Newcastle upon Tyne

SO16 6YD

Southampton

WN6 9EW

Wigan

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT00316771 - A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy | Biotech Hunter | Biotech Hunter