Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents

PHASE3CompletedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

April 30, 2006

Primary Completion Date

May 31, 2010

Study Completion Date

March 2, 2017

Conditions
Pain
Interventions
DRUG

Gabapentin

Gabapentin will be prescribed at 900mg/d (300mg tid). A dose escalation schedule will be followed: one pill taken at night (\~2000h) for the first 3 days, one pill at night and one pill in the morning (\~0800h) for the second 3 days and finally, one pill at night, one in the morning and one mid-afternoon (\~1400h) for the reminder of the trial.

DRUG

Amitriptyline

Amitriptyline will be prescribed at a dose of 10mg (qhs). A dose escalation schedule will be followed: one pill taken at night (\~2000h) for the first 3 days, one pill at night and one pill in the morning (\~0800h) for the second 3 days and finally, one pill at night, one in the morning and one mid-afternoon (\~1400h) for the reminder of the trial.

Trial Locations (1)

M5G 1X8

The Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

The Hospital for Sick Children

OTHER

NCT00312260 - Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents | Biotech Hunter | Biotech Hunter