Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses

PHASE4CompletedINTERVENTIONAL
Enrollment

331

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

February 28, 2010

Study Completion Date

February 28, 2010

Conditions
Depression
Interventions
DEVICE

VNS Therapy

Received output current of 0.25 milliamps (mA)

DEVICE

VNS Therapy

Received output current of 0.5-1.0 mA

DEVICE

VNS Therapy

Received output current of 1.0-1.5 mA

Trial Locations (26)

10021

Eastside Comprehensive Medical Center, New York

10032

New York State Psychiatric Institute, New York

13210

SUNY Upstate Medical University, Syracuse

14226

Dent Neurologic Institute, Amherst

15213

University of Pittsburgh, Pittsburgh

17033

Penn State Milton S. Hershey Medical Center, Hershey

19104

University of Pennsylvania, Philadelphia

21204

Sheppard Pratt Hospital, Baltimore

21208

Pharmasite Research Inc., Baltimore

30060

Northwest Behavioral Research Center, Marietta

55114

Psychiatric Recovery, Saint Paul

60201

Evanston Northwestern Hospital, Evanston

63104

St. Louis University, St Louis

67211

Clinical Research Institute, Wichita

71101

Brentwood Research Institute, Shreveport

77401

Claghorn-Lesem Research Clinic, LTD, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

78756

Community Clinical Research, Inc., Austin

85724

University of Arizona, Tucson

95816

Sutter Institute for Medical Research, Sacramento

97239

Oregon Health & Science University, Portland

98040

Center for Anxiety and Depression, Mercer Island

02129

Massachusetts General Hospital, Charlestown

02906

Butler Hospital, Providence

75235-8898

UT Southwestern Medical Center, Dallas

84132-2502

University of Utah, Salt Lake City

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cyberonics, Inc.

INDUSTRY

NCT00305565 - Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses | Biotech Hunter | Biotech Hunter