1,173
Participants
Start Date
January 31, 2006
Primary Completion Date
February 28, 2011
Study Completion Date
December 31, 2016
Concurrent temozolomide
Daily oral temozolomide (75 mg/m2) up to 49 doses.
Concurrent radiation therapy
60 Gy in 2 Gy fractions
100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle
Oral temozolomide on days 1-5 of a 28-day cycle. Dose starts at 150mg/m2 for first cycle, increases to 200mg/m2 for subsequent cycles if no unacceptable toxicity. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding disease may receive up to 6 more courses of temozolomide.
75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle
Oral temozolomide on days 1-21 of a 28-day cycle. Dose starts at 75mg/m2 for first cycle, increases to 100mg/m2 for subsequent cycles if no unacceptable toxicity. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding disease may receive up to 6 more courses of temozolomide.
Memorial Sloan-Kettering Cancer Center, New York
CCOP - North Shore University Hospital, Manhasset
Don Monti Comprehensive Cancer Center at North Shore University Hospital, Manhasset
Long Island Jewish Medical Center, New Hyde Park
Monter Cancer Center of the North Shore-LIJ Health System, Lake Success
New York Methodist Hospital, Brooklyn
Hudson Valley Oncology Associates, Poughkeepsie
Lipson Cancer and Blood Center at Rochester General Hospital, Rochester
Alle-Kiski Medical Center, Natrona Heights
Intercommunity Cancer Center, Monroeville
Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh
Somerset Oncology Center, Somerset
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg
Upper Delaware Valley Cancer Center, Milford
Northeast Radiation Oncology Center, Dunmore
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre
Rosenfeld Cancer Center at Abington Memorial Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
Riddle Memorial Hospital Cancer Center, Media
CCOP - Main Line Health, Wynnewood
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia
CCOP - Christiana Care Health Services, Newark
Tunnell Cancer Center at Beebe Medical Center, Lewes
St. Agnes Hospital Cancer Center, Baltimore
DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis
Union Hospital Cancer Program at Union Hospital, Elkton
Fredericksburg Oncology, Incorporated, Fredericksburg
Sentara Cancer Institute at Sentara Norfolk General Hospital, Norfolk
Wayne Memorial Hospital, Incorporated, Goldsboro
Wayne Radiation Oncology, Goldsboro
Wilmed Radiation Oncology Services, Wilson
Rutherford Hospital, Rutherfordton
Mission Hospitals - Memorial Campus, Asheville
CCOP - Upstate Carolina, Spartanburg
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg
Hollings Cancer Center at Medical University of South Carolina, Charleston
AnMed Cancer Center, Anderson
Piedmont Hospital, Atlanta
John B. Amos Cancer Center, Columbus
Integrated Community Oncology Network - Orange Park, Orange Park
Flagler Cancer Center, Saint Augustine
Florida Cancer Center - Palatka, Palatka
Baptist Cancer Institute - Jacksonville, Jacksonville
Integrated Community Oncology Network at Southside Cancer Center, Jacksonville
Mayo Clinic - Jacksonville, Jacksonville
Integrated Community Oncology Network, Jacksonville Beach
Baptist Medical Center South, Jacksonville
Baptist-South Miami Regional Cancer Program, Miami
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus, Boca Raton
Thompson Cancer Survival Center West, Knoxville
Thompson Cancer Survival Center at Methodist, Oak Ridge
Thompson Cancer Survival Center, Knoxville
Grady Memorial Hospital, Delaware
Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark
Mount Carmel St. Ann's Cancer Center, Westerville
Fairfield Medical Center, Lancaster
CCOP - Columbus, Columbus
Grant Medical Center Cancer Care, Columbus
Mount Carmel Health - West Hospital, Columbus
Doctors Hospital at Ohio Health, Columbus
Mary Rutan Hospital, Bellefontaine
Wood County Oncology Center, Bowling Green
Northwest Ohio Oncology Center, Maumee
St. Luke's Hospital, Maumee
Flower Hospital Cancer Center, Sylvania
Fulton County Health Center, Wauseon
Toledo Hospital, Toledo
St. Vincent Mercy Medical Center, Toledo
Medical University of Ohio Cancer Center, Toledo
St. Charles Mercy Hospital, Oregon
Toledo Clinic - Oregon, Oregon
CCOP - Toledo Community Hospital, Toledo
Toledo Clinic, Incorporated - Main Clinic, Toledo
Genesis - Good Samaritan Hospital, Zanesville
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland
Cleveland Clinic Cancer Center, Independence
Cleveland Clinic Taussig Cancer Center, Cleveland
McDowell Cancer Center at Akron General Medical Center, Akron
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem
Cancer Treatment Center, Wooster
North Coast Cancer Care, Incorporated, Sandusky
Mercy Hospital of Tiffin, Tiffin
Mercy Medical Center, Springfield
Community Hospital of Springfield and Clark County, Springfield
Adena Regional Medical Center, Chillicothe
Strecker Cancer Center at Marietta Memorial Hospital, Marietta
Lima Memorial Hospital, Lima
Central Indiana Cancer Centers - East, Indianapolis
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte
Saint Anthony Memorial Health Centers, Michigan City
Elkhart General Hospital, Elkhart
CCOP - Northern Indiana CR Consortium, South Bend
Memorial Hospital of South Bend, South Bend
Saint Joseph Regional Medical Center, South Bend
South Bend Clinic, South Bend
Radiation Oncology Associates Southwest, Fort Wayne
Parkview Regional Cancer Center at Parkview Health, Fort Wayne
Howard Community Hospital, Kokomo
Mercy Regional Cancer Center at Mercy Hospital, Port Huron
William Beaumont Hospital - Royal Oak Campus, Royal Oak
Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield
St. John Macomb Hospital, Warren
CCOP - Michigan Cancer Research Consortium, Ann Arbor
Haematology-Oncology Associates of Ohio and Michigan, PC, Lambertville
St. Mary Mercy Hospital, Livonia
Community Cancer Center of Monroe, Monroe
Mercy Memorial Hospital - Monroe, Monroe
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw
Borgess Medical Center, Kalamazoo
Bronson Methodist Hospital, Kalamazoo
Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph
Foote Memorial Hospital, Jackson
Hickman Cancer Center at Bixby Medical Center, Adrian
Green Bay Oncology, Limited - Escanaba, Escanaba
Dickinson County Healthcare System, Iron Mountain
McFarland Clinic, PC, Ames
Mercy Capitol Hospital, Des Moines
CCOP - Iowa Oncology Research Association, Des Moines
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines
Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines
Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines
John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City
Community Memorial Hospital Cancer Care Center, Menomonee Falls
Regional Cancer Center at Oconomowoc Memorial Hospital, Oconomowoc
Waukesha Memorial Hospital Regional Cancer Center, Waukesha
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Green Bay Oncology, Limited - Oconto Falls, Oconto Falls
Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay
St. Mary's Hospital Medical Center - Green Bay, Green Bay
Gundersen Lutheran Center for Cancer and Blood, La Crosse
Theda Care Cancer Institute, Appleton
United Hospital, Saint Paul
Minnesota Oncology Hematology, PA - Maplewood, Maplewood
Minnesota Oncology Hematology, PA - Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Ridgeview Medical Center, Waconia
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis
CCOP - Metro-Minnesota, Saint Louis Park
Park Nicollet Cancer Center, Saint Louis Park
Mercy and Unity Cancer Center at Unity Hospital, Fridley
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Mayo Clinic Cancer Center, Rochester
CentraCare Clinic - River Campus, Saint Cloud
Coborn Cancer Center, Saint Cloud
Alexandria
Fergus Falls
MeritCare Bemidji, Bemidji
Avera Cancer Institute, Sioux Falls
Medical X-Ray Center, PC, Sioux Falls
Rapid City Regional Hospital, Rapid City
CCOP - MeritCare Hospital, Fargo
MeritCare Broadway, Fargo
CCOP - Montana Cancer Consortium, Billings
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings
Northern Rockies Radiation Oncology Center, Billings
St. Vincent Healthcare Cancer Care Services, Billings
Great Falls Clinic - Main Facility, Great Falls
Great Falls
Northern Montana Hospital, Havre
St. James Healthcare Cancer Care, Butte
Community Medical Center, Missoula
Guardian Oncology and Center for Wellness, Missoula
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula
Glacier Oncology, PLLC, Kalispell
Kalispell Medical Oncology at KRMC, Kalispell
Kalispell Regional Medical Center, Kalispell
Northwest Community Hospital, Arlington Heights
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Joliet Oncology-Hematology Associates, Limited - West, Joliet
Rush-Copley Cancer Care Center, Aurora
Community Hospital of Ottawa, Ottawa
Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa
Illinois Valley Community Hospital, Peru
Perry Memorial Hospital, Princeton
St. Margaret's Hospital, Spring Valley
Valley Cancer Center, Spring Valley
Galesburg Clinic, PC, Galesburg
Galesburg Cottage Hospital, Galesburg
InterCommunity Cancer Center of Western Illinois, Galesburg
McDonough District Hospital, Macomb
Graham Hospital, Canton
Eureka Community Hospital, Eureka
Cancer Treatment Center at Pekin Hospital, Pekin
Proctor Hospital, Peoria
CCOP - Illinois Oncology Research Association, Peoria
Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
St. Joseph Medical Center, Bloomington
Hopedale Medical Complex, Hopedale
BroMenn Regional Medical Center, Normal
Community Cancer Center, Normal
Carle Cancer Center at Carle Foundation Hospital, Urbana
CCOP - Carle Cancer Center, Urbana
Memorial Hospital, Carthage
Mason District Hospital, Havana
Independence Regional Health Center, Independence
Liberty Hospital, Liberty
Truman Medical Center - Hospital Hill, Kansas City
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City
St. Joseph Medical Center, Kansas City
North Kansas City Hospital, Kansas City
Parvin Radiation Oncology, Kansas City
CCOP - Kansas City, Kansas City
Kansas City Cancer Centers - South, Kansas City
Research Medical Center, Kansas City
Heartland Regional Medical Center, Saint Joseph
St. John's Regional Medical Center, Joplin
CCOP - Cancer Research for the Ozarks, Springfield
St. John's Regional Health Center, Springfield
Hulston Cancer Center at Cox Medical Center South, Springfield
Shawnee Mission Medical Center, Shawnee Mission
Menorah Medical Center, Overland Park
Kansas City Cancer Centers - Southwest, Overland Park
Cancer Center of Kansas, PA - Chanute, Chanute
Cancer Center of Kansas, PA - El Dorado, El Dorado
Cancer Center of Kansas, PA - Salina, Salina
Cancer Center of Kansas, PA - Kingman, Kingman
Cancer Center of Kansas, PA - Newton, Newton
Cancer Center of Kansas, PA - Pratt, Pratt
Cancer Center of Kansas, PA - Wellington, Wellington
Cancer Center of Kansas, PA - Winfield, Winfield
Associates in Womens Health, PA - North Review, Wichita
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita
Cancer Center of Kansas, PA - Wichita, Wichita
CCOP - Wichita, Wichita
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita
Wesley Medical Center, Wichita
Cancer Center of Kansas-Independence, Independence
Cancer Center of Kansas, PA - Parsons, Parsons
Cancer Center of Kansas, PA - Dodge City, Dodge City
Southwest Medical Center, Liberal
CCOP - Missouri Valley Cancer Consortium, Omaha
Methodist Estabrook Cancer Center, Omaha
Immanuel Medical Center, Omaha
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha
Cancer Resource Center - Lincoln, Lincoln
Oklahoma University Cancer Institute, Oklahoma City
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa
Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman
Medical City Dallas Hospital, Dallas
Texas Oncology, PA at Texas Cancer Center Dallas Southwest, Dallas
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land
Poudre Valley Radiation Oncology, Fort Collins
Penrose Cancer Center at Penrose Hospital, Colorado Springs
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise
American Fork Hospital, American Fork
LDS Hospital, Salt Lake City
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Huntsman Cancer Institute at University of Utah, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Sandra L. Maxwell Cancer Center, Cedar City
Dixie Regional Medical Center - East Campus, St. George
Arizona Oncology Services Foundation, Phoenix
Arizona Oncology - Tucson, Tucson
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
Kaiser Permanente Medical Center - Los Angeles, Los Angeles
Providence Saint Joseph Medical Center - Burbank, Burbank
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Auburn Radiation Oncology, Auburn
Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael
Radiation Oncology Center - Roseville, Roseville
Radiation Oncology Centers - Cameron Park, Cameron Park
Solano Radiation Oncology Center, Vacaville
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento
Mercy General Hospital, Sacramento
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital & Comprehensive Cancer Center, Portland
Adventist Medical Center, Portland
Providence Milwaukie Hospital, Milwaukie
CCOP - Columbia River Oncology Program, Portland
Providence St. Vincent Medical Center, Portland
Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland
Willamette Valley Cancer Center - Eugene, Eugene
St. Francis Hospital, Federal Way
Cascade Cancer Center at Evergreen Hospital Medical Center, Kirkland
CCOP - Virginia Mason Research Center, Seattle
St. Joseph Cancer Center, Bellingham
Southwest Washington Medical Center Cancer Center, Vancouver
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital, Fairbanks
Mayo Clinic Scottsdale, Scottsdale
City of Hope Comprehensive Cancer Center, Duarte
Yale Cancer Center, New Haven
University of Florida Shands Cancer Center, Gainesville
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa
John H. Stroger, Jr. Hospital of Cook County, Chicago
University of Chicago Cancer Research Center, Chicago
OSF St. Francis Medical Center, Peoria
Saint Joseph Mercy Cancer Center, Ann Arbor
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn
West Michigan Cancer Center, Kalamazoo
Sparrow Regional Cancer Center, Lansing
St. Joseph Mercy Oakland, Pontiac
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale
Billings Clinic - Downtown, Billings
Montana Cancer Specialists at Montana Cancer Center, Missoula
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney
Creighton University Medical Center, Omaha
Dartmouth - Hitchcock Concord, Concord
Kingsbury Center for Cancer Care at Cheshire Medical Center, Keene
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
St. Barnabas Medical Center Cancer Center, Livingston
Frederick R. and Betty M. Smith Cancer Treatment Center, Sparta
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township
Summa Center for Cancer Care at Akron City Hospital, Akron
Aultman Cancer Center at Aultman Hospital, Canton
Riverside Methodist Hospital Cancer Care, Columbus
Providence Cancer Center at Providence Portland Medical Center, Portland
Salem Hospital Regional Cancer Care Services, Salem
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Cancer Center of Paoli Memorial Hospital, Paoli
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Fox Chase Cancer Center - Philadelphia, Philadelphia
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
M. D. Anderson Cancer Center at University of Texas, Houston
Joe Arrington Cancer Research and Treatment Center, Lubbock
Fletcher Allen Health Care - University Health Center Campus, Burlington
Norris Cotton Cancer Center - North, Saint Johnsbury
Virginia Commonwealth University Massey Cancer Center, Richmond
University Cancer Center at University of Washington Medical Center, Seattle
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison
Door County Cancer Center at Door County Memorial Hospital, Sturgeon Bay
Tom Baker Cancer Centre - Calgary, Calgary
CancerCare Manitoba, Winnipeg
Saint John Regional Hospital, Saint John
Margaret and Charles Juravinski Cancer Centre, Hamilton
Ottawa Hospital Regional Cancer Centre - General Campus, Ottawa
Cancer Care Program at Thunder Bay Regional Health Sciences, Thunder Bay
Princess Margaret Hospital, Toronto
McGill Cancer Centre at McGill University, Montreal
Centre Hospitalier Universitaire de Quebec, Québec
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Collaborators (1)
National Cancer Institute (NCI)
NIH
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK