926
Participants
Start Date
February 28, 2006
Primary Completion Date
October 31, 2007
Study Completion Date
February 28, 2009
Nexavar (Sorafenib, BAY43-9006) + carboplatin + paclitaxel
Chemotherapy Phase up to 6 cycles: Sorafenib (Nexavar, BAY43-9006), \[400 mg orally, twice daily\] on Study Days 2-19 and paclitaxel (P) (200 mg/m2, intravenous (IV)) and carboplatin (C) (area under the curve (AUC) =6 mg/ml\*min-1, IV) on Study Day 1. The cycle duration 21 days. Maintenance Phase: Sorafenib 400 mg orally twice daily was administered on Days 1-21 of each 21-day cycle.
Carboplatin plus Paclitaxel
Chemotherapy Phase up to 6 cycles: Sorafenib Placebo (2 tablets orally twice daily\] on Study Days 2-19 and paclitaxel (200 mg/m2, intravenous (IV)) and carboplatin (area under the curve (AUC) =6 mg/ml\*min-1, IV) on Study Day 1. The cycle duration 21 days. Maintenance Phase: Sorafenib Placebo 2 tablets orally twice daily was administered on Days 1-21 of each 21-day cycle.
Taipei
Taoyuan District
Bruxelles - Brussel
Budapest
El Palomar - Morón
Rosario
Törökbálint
Port Macquarie
Wollongong
Melbourne
Frankston
Mátraháza
Liège
Brisbane
Adelaide
Gyula
Perth
Charleroi
Deszk
La Louvière
New York
Orbassano
Torino
Staten Island
Berlin
Caen
Rochester
Genova
Pottsville
Bethlehem
Allentown
Sayre
Philadelphia
Milan
Hamburg
Fairfax
Großhansdorf
Richmond
Bergamo
Abingdon
Richlands
Oldenburg
Morgantown
Pavia
Madrid
Madrid
Majadahonda
Charleston
Greenville
Marietta
Atlanta
Hanover
Savannah
Orlando
Orlando
Merritt Island
Lakeland
Birmingham
Pontevedra
Mobile
Göttingen
Knoxville
Hattiesburg
Louisville
Taichung
Parma
Columbus
Columbus
Dover
Essen
Essen
Dayton
Indianapolis
Indianapolis
Indianapolis
Fort Wayne
Kokomo
Ann Arbor
Detroit
Zamora
Zaragoza
Sioux City
Leverkusen
Milwaukee
Nancy
Mainz
Metz
Fargo
Bismarck
Hemer
Skokie
Skokie
Chicago
St Louis
Kansas City
Kansas City
Jefferson City
Hofheim
Strasbourg
Wichita
Hutchinson
Mannheim
Lincoln
Heidelberg
Metairie
Baton Rouge
Little Rock
Springdale
Oklahoma City
Tulsa
Trophy Club
Denver
München
Gauting
Salt Lake City
Tucson
Las Vegas
Las Vegas
Los Angeles
Burbank
Encinitas
Clamart
Highland
Anaheim
Corona
Orange
Bobigny
Sacramento
Portland
Moscow
Moscow
Seoul
Seoul
Moscow
Saint Petersburg
Barretos
Belo Horizonte
Nova Lima
Salvador
Brasília
Porto Alegre
Beverly Hills
Boston
Pittsfield
Hackensack
Morristown
Nashville
Richmond
La Plata
Mar del Plata
Buenos Aires
Capital Federal-Buenos Aires
Santa Fé
Fortaleza
Fortaleza
Goiânia
Curitiba
Porto Alegre
Joinville
Jaú
Ribeirão Preto
Santo André
São Paulo
São Paulo
São Paulo
São Paulo
Santiago
Hong Kong
Sorocaba
North Vancouver
Barrie
Brampton
Montreal
Regina
Santiago
Santiago
Santiago
Nice
Perugia
Roma
Eindhoven
Zwolle
Gdansk
Krakow
Olsztyn
Otwock
Warsaw
Warsaw
Wroclaw
San Juan
Seoul
Alicante
Elche
Barcelona
Gävle
Stockholm
Uppsala
Plymouth
Bornemouth
Leicester
London
Manchester
Lead Sponsor
Bayer
INDUSTRY