126
Participants
Start Date
June 30, 2006
Primary Completion Date
November 30, 2015
Study Completion Date
December 31, 2015
thymectomy plus prednisone
The thymectomy will be performed as soon as possible after randomization.
prednisone alone
Prednisone regimen will be every other day, starting at 10mg. The dose will increase by 10mg every 2 days to a target dose.
University of Melbourne, Melbourne, The Royal Melbourne Hospital, Dept of Neurology, Royal Melbourne Hospital, Victoria
Mount Sinai Hospital,1 Gustave L. Levy Pl, New York
Ramathibodi Hospital, Mahidol University, Bangkok
Instituto Nacional de la Nutrición, México
University of Rochester, 601 Elmwood Ave, Rochester
"National Neurological Institute Carlo Besta, Myopathology and Immunology Unit, Dept of Neurology IV, Natl. Neurolog Inst. C. Besta, Via Celoria, 11,", Milan
University of Virginia, 1215 Lee St, Charlottesville
Fu-Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist, New Taipei City
West Virginia University, Dept of Neurology, WVU Eye Institute, Neurology Suite, 1 Stadium Drive,, Morgantown
Duke University, 200 Trent Dr, Durham
Emory University, 201 Dowman Dr, Atlanta
Augusta University, 1120 15th St, Augusta
University of Florida Jacksonville, Tower I, 8th Floor, 580 W. 8th ST., Jacksonville
University of Miami, 1120 NW 14th Street, Suite 1300, Miami
University of Alabama at Birmingham, Department of Neurology, Sparks Center, Suite 350, 1720 7th Avenue South, Birmingham
Data Coordination Center: University of Alabama at Birmingham, Birmingham
The Ohio State University Wexmer Medical Center, Rm 461 Means Hall, The Ohio State University Medical Center,1654 Upham Dr., Columbus
Case Western Reserve University, University Hospitals of Cleveland, 1100 Euclid Avenue, Cleveland
William Beaumont Hospital, 3601 W. Thirteen Mile Road, Royal Oak, Royal Oak
University of Münster, Schlossplatz 2, Münster
Wayne State University School of Medicine, 4201 St Antoine, 8D UHC, Detroit
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee
Johannes-Gutenberg University, Klinikum der Johannes Gutenberg-Universität, Klinik und Poliklinik für Neurologie, Langenbeckstr, Mainz
University of Minnesota, Department of Neurology, MMC 295, 420 Delaware St. S.E.,, Minneapolis
Mayo Clinic Rochester, 200 First St. SW, Rochester
The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City
University of Heidelberg, Seminarstraße 2, Mannheim
University of Tübingen, Tübingen
Nerve and Muscle Center of Texas, 6624 Fannin St # 1670, Houston
Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, 350 W Thomas Rd, Phoenix
University of Southern California, Doheny Institute, 1450 San Pablo St, Los Angeles
University of California Irvine, 101 The City Drive S, Bldg. 22 C, Route 13, Orange
University of Regensburg, Dept. of Neurology, Universitätsstr. 84, D, Regensburg
California Pacific Medical Center, Castro St & Duboce Ave, San Francisco
University of Washington, 1410 NE Campus Pkwy, Seattle
Indiana University, Dept of Neurology, Regenstrief Health Center, 6th floor, 1050 Walnut St, Indiana University Medical Center, Indianapolis
Brigham and Women's Hospital, 75 Francis Street, 5th Floor Tower, Boston
St. Louis University, One North Grand St. Louis, St Louis
Robert Wood Johnson University,, New Brunswick
University of Texas Southwestern Medical Center, 5232 Harry Hines Blvd,, Dallas
University of Texas Medical Branch, 301 University Blvd, Galveston
University of Texas Health Science Center, Mail code 7883, 7703 Floyd Curl Drive, San Antonio
University of Vermont College of Medicine, Given Bldg C225, 89 Beaumont Avenue, Burlington
University of Buenis, Centro de Asistencia Docencia e Investigacion en Miastenia (CADIMI) Av. Forest 1146 - Ciudad Autonoma de Buenos Aires, Buenos Aires
University of Sydney, Royal Prince Alfred Hospital and The University of Sydney, Sydney
Hospital Del Salvador, Departamento de Ciencias Neurológicas, Universidad de Chile, Salvador 95 Of 416, Providencia, Santiago
Catholic University, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, e, Rome
University of Torino, Torino
Leiden University, Leiden
Institute of Tuberculosis and Lung Disease, Warsaw
University of Cape Town, Division of Neurology E8-74, Groote Schuur Hospital,Observatory, Cape Town
Hospital de Base do Distrito Federal, Brasília
Universidade Federal do Parana, Curitiba
Federal University of Rio De Janeiro, Rio de Janeiro
University of Calgary, Heritage Medical Research Clinic Room 1132 3330 Hospital Dr NW, Calgary
University of British Columbia, Vancouver
University of Ottawa, The Ottawa Hospital General Campus, Division of Neurology, 501 Smyth Rd. Box 601, Ottawa
McGill University Health Center, Montreal
University of Düsseldorf, Düsseldorf
"University of Rome Sapienza", Rome
Kanazawa University, Department of Neurology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa
Nagasaki University, First Department of Internal Medicine,Graduate School of Biomedical Sciences,1-7-1,Sakamoto, Nagasaki
Medical University of Warsaw, Warsaw
Porto University, Serviço de Neurologia,Hospital Geral de Santo António, Largo Prof Abel Salazar, Porto
H. Sant Pau, Universitat Autònoma de Barcelona, Neurology Department, Hospital Sta Creu i Sant Pau, C/Mas Casanovas no 90 4o pis 4o modul., Barcelona
Queen Elizabeth University Hospital, Glasgow, Glasgow
Walton Centre for Neurology and Neurosurgery, Liverpool Heart and Chest Hospital, Liverpool. The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool
University of Manchester, Oxford Road, Manchester
University of Oxford, Dept of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford
University of Sheffield, Western Bank, Sheffield
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University of Alabama at Birmingham
OTHER