Rituximab, Fludarabine, Mitoxantrone, Dexamethasone (R-FND) Plus Zevalin for High-Risk Follicular Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

June 29, 2004

Primary Completion Date

February 12, 2021

Study Completion Date

February 12, 2021

Conditions
Lymphoma
Interventions
DRUG

Fludarabine

25 mg/m\^2 intravenous (IV) over 5-30 minutes on Days 2-4.

DRUG

Mitoxantrone

10 mg/m\^2 IV over 5-30 minutes on Day 2.

DRUG

Rituximab

375 mg/m\^2 IV over 4-6 hours on Day 1 and 8; maintenance Rituximab = 375 mg/m\^2 IV over 4-6 hours on Day 1 only, a single dose every other month for 12 months (6 doses total).

DRUG

Zevalin

0.3 mCi/kg IV after 4 cycles of R-FND.

DRUG

Dexamethasone

20 mg by mouth (PO) or IV daily on Days 2-6.

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Biogen

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER