Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With Hypercholesterolemia

PHASE3CompletedINTERVENTIONAL
Enrollment

1,362

Participants

Timeline

Start Date

March 31, 2006

Primary Completion Date

May 31, 2007

Study Completion Date

May 31, 2007

Conditions
Hypercholesterolemia
Interventions
DRUG

Lapaquistat acetate and simvastatin

Lapaquistat acetate 50 mg, tablets, orally, once daily and stable dose of simvastatin for up to 12 weeks.

DRUG

Lapaquistat acetate and simvastatin

Lapaquistat acetate 100 mg, tablets, orally, once daily and stable dose of simvastatin for up to 12 weeks.

DRUG

Simvastatin

Lapaquistat acetate placebo-matching tablets, orally, once daily and stable dose of simvastatin for up to 12 weeks.

Trial Locations (67)

Unknown

Huntsville

Chandler

Scottsdale

Sierra Vista

Tucson

Beverly Hills

Long Beach

Sacramento

Spring Valley

Colorado Springs

Hialeah

Hollywood

Jacksonville

Jupiter

Kissimmee

Miami

Ocala

Pembroke Pines

Pinellas Park

Stuart

West Palm Beach

Arlington Heights

Chicago

Peoria

Indianapolis

Overland Park

Wichita

Louisville

Edina

St Louis

Las Vegas

Margate City

Raleigh

Statesville

Winston-Salem

Cincinnati

Columbus

Kettering

Bartlesville

Portland

Beaver

Downingtown

Tipton

Goose Creek

Jackson

Nashville

San Antonio

Norfolk

Richmond

Lakewood

Abbotsford

Coquitlam

Victoria

Winnipeg

Mount Pearl

St. John's

Cornwall

London

Oakville

Oshawa

Thornhill

Toronto

Cornwall

Mirabel

Saint-Lambert

Sherbrooke

Ste-Foy

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY