30
Participants
Start Date
September 30, 2005
Primary Completion Date
April 30, 2012
Study Completion Date
December 31, 2012
bevacizumab
Bevacizumab IV over 30-90 minutes once every 2 weeks for up to 1 year. Bevacizumab, which stops 8 weeks before surgery, may restart 4 weeks after surgery and continue for 9 months in the absence of disease progression or unacceptable toxicity.
docetaxel
docetaxel IV over 1 hour once a week for 8 weeks
conventional surgery
8-10 weeks after the completion of chemoradiotherapy, patients may undergo neck dissection
radiation therapy
radiotherapy once daily, 5 days a week, for 8 weeks
UPMC Cancer Centers, Pittsburgh
Lake/University Ireland Cancer Center, Mentor
UHHS Chagrin Highlands Medical Center, Orange Villager
Southwest General Health Center, Middleburg Heights
UHHS Westlake Medical Center, Westlaker
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
National Cancer Institute (NCI)
NIH
Case Comprehensive Cancer Center
OTHER