Protocol for the Treatment of Patients With Previously Untreated Chronic Lymphocytic Leukemia

Fludarabine is usually administered by IV infusion over 30 minutes or longer.

The dosage is a solution of 20 mg/mI. IV infusion over 1 hour.

First Infusion: The rituximab solution for infusion should be administered intravenously at an initial rate of 50 mg/hr. Subsequent rituximab infusions can be administered at an initial rate of 100 mg/hr, and increased by 100 mg/hr increments at 30-minute intervals, to a maximum of 400 mg/hr as tolerated.