Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

February 20, 2006

Primary Completion Date

December 31, 2014

Study Completion Date

September 30, 2022

Conditions
Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7Stage II Nasopharyngeal Undifferentiated Carcinoma AJCC v7Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7Stage III Nasopharyngeal Undifferentiated Carcinoma AJCC v7Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7
Interventions
DRUG

Amifostine

Given subcutaneously

DRUG

Cisplatin

Given IV

DRUG

Fluorouracil

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

RADIATION

Radiation Therapy

Undergo radiotherapy

Trial Locations (109)

6008

Princess Margaret Hospital for Children, Perth

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10595

New York Medical College, Valhalla

13210

State University of New York Upstate Medical University, Syracuse

14642

University of Rochester, Rochester

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Penn State Children's Hospital, Hershey

19104

Children's Hospital of Philadelphia, Philadelphia

19134

Saint Christopher's Hospital for Children, Philadelphia

20007

MedStar Georgetown University Hospital, Washington D.C.

20010

Children's National Medical Center, Washington D.C.

21215

Sinai Hospital of Baltimore, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22042

Inova Fairfax Hospital, Falls Church

23507

Children's Hospital of The King's Daughters, Norfolk

25304

West Virginia University Charleston Division, Charleston

27710

Duke University Medical Center, Durham

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29203

Prisma Health Richland Hospital, Columbia

29605

BI-LO Charities Children's Cancer Center, Greenville

Greenville Cancer Treatment Center, Greenville

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

Emory University Hospital/Winship Cancer Institute, Atlanta

32207

Nemours Children's Clinic-Jacksonville, Jacksonville

32806

Arnold Palmer Hospital for Children, Orlando

Orlando Health Cancer Institute, Orlando

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Nicklaus Children's Hospital, Miami

33407

Saint Mary's Hospital, West Palm Beach

33607

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33701

Johns Hopkins All Children's Hospital, St. Petersburg

33901

Lee Memorial Health System, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

University of Alabama at Birmingham Cancer Center, Birmingham

37916

East Tennessee Childrens Hospital, Knoxville

38105

Saint Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

Norton Children's Hospital, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

43205

Nationwide Children's Hospital, Columbus

43608

Mercy Children's Hospital, Toledo

43614

University of Toledo, Toledo

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

Dayton Children's Hospital, Dayton

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

Riley Hospital for Children, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Ascension Saint John Hospital, Detroit

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

53226

Children's Hospital of Wisconsin, Milwaukee

55905

Mayo Clinic in Rochester, Rochester

58122

Sanford Broadway Medical Center, Fargo

60611

Lurie Children's Hospital-Chicago, Chicago

62702

Southern Illinois University School of Medicine, Springfield

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

Washington University School of Medicine, St Louis

64108

Children's Mercy Hospitals and Clinics, Kansas City

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University Health Sciences Center, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

Cook Children's Medical Center, Fort Worth

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

78229

Methodist Children's Hospital of South Texas, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

80045

Children's Hospital Colorado, Aurora

84113

Primary Children's Hospital, Salt Lake City

85719

Banner University Medical Center - Tucson, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

89135

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89169

Nevada Cancer Research Foundation NCORP, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

90095

Mattel Children's Hospital UCLA, Los Angeles

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

90242

Kaiser Permanente Downey Medical Center, Downey

93636

Valley Children's Hospital, Madera

94115

UCSF Medical Center-Mount Zion, San Francisco

94143

UCSF Medical Center-Parnassus, San Francisco

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

96813

University of Hawaii Cancer Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

Arkansas Children's Hospital, Little Rock

06030

University of Connecticut, Farmington

06106

Connecticut Children's Medical Center, Hartford

20889-5600

Walter Reed National Military Medical Center, Bethesda

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

08903

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07902

Overlook Hospital, Summit

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

T3B 6A8

Alberta Children's Hospital, Calgary

V6H 3V4

British Columbia Children's Hospital, Vancouver

B3K 6R8

IWK Health Centre, Halifax

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Québec

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00274937 - Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer | Biotech Hunter | Biotech Hunter