Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

December 31, 2005

Primary Completion Date

January 31, 2009

Study Completion Date

January 31, 2009

Conditions
Carcinoma, Non-Small-Cell LungLung Neoplasms
Interventions
DRUG

HKI-272

320mg or 240mg daily by mouth. The starting dose was reduced from 320mg to 240mg per amendment #1 to the protocol for subject safety and tolerability.

Trial Locations (19)

10021

Memorial Sloan-Kettering, New York

28203

Carolinas Hematology-Oncology Associates, Charlotte

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic, Cleveland

55455

University of Minnesota, Minneapolis

60099

Midwestern Regional Medical Center, Zion

90033

USC Norris Comprehensive Cancer Center, Los Angeles

94805

Institut Gustave Roussy, Villejuif

98104

Swedish Cancer Institute, Seattle

98109

Seattle Cancer Care Alliance, Seattle

02114

Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston

37232-6868

Vanderbilt University Medical Center, Nashville

H-1529

Országos Korányi TBC és Pulmonológiai Intézet, Budapest

H-4012

University of Debrecen, Debrecen

80-952

Akademia Medyczna W Gdansku, Gdansk

05-400

Mazowieckie Centrum Leczenia Chorób Płuc i Gruźlicy, Otwock

60-569

Wielkopolskie Centrum Chorób Płuc i Gruźlicy, Poznan

54-439

Dolnośląskie Centrum Chorób Płuc we Wrocławiu, Wroclaw

08916

Hospital Germans Trias I Puyol, Badalona

All Listed Sponsors
lead

Puma Biotechnology, Inc.

INDUSTRY

NCT00266877 - Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter