Preoperative Radiotherapy/ Oxaliplatin/ Capecitabine Treatment For Unresectable Locally-advanced Rectal Cancer

PHASE2CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

June 30, 2002

Primary Completion Date

March 31, 2007

Conditions

Rectal Neoplasms

Interventions

DRUG

Oxaliplatin

60mg/m² as a 2-hour intravenous infusion every week for 5-6 week

DRUG

Capecitabine

500mg tablets and 150mg tablets. 750mg/m² bd given approximately 12 hours apart

RADIATION

Radiotherapy

Planned total dose of 45-50.4Gy (with cone down) in 25-28 fractions