Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias

NACompletedINTERVENTIONAL
Enrollment

4

Participants

Timeline

Start Date

October 31, 2005

Primary Completion Date

November 30, 2008

Study Completion Date

February 28, 2009

Conditions
Anemia, AplasticAmegakaryocytic ThrombocytopeniaDiamond-Blackfan AnemiaKostmann Syndrome
Interventions
DEVICE

Allogeneic stem cell transplant

Participants will receive a reduced intensity conditioning regimen consisting of fludarabine, thiotepa, melphalan, and OKT3 followed by an infusion of haploidentical stem cells. Rituximab will be administered within 24 hours of the infusion in an effort to prevent posttransplant lymphoproliferative disorder LPD. In addition to T-cell depletion of the donor product, participant will receive mycophenolate mofetil for prophylaxis of GVHD.

Trial Locations (1)

38105

St. Jude Children's Research Hospital, Memphis

All Listed Sponsors
lead

St. Jude Children's Research Hospital

OTHER

NCT00244010 - Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias | Biotech Hunter | Biotech Hunter