4
Participants
Start Date
October 31, 2005
Primary Completion Date
November 30, 2008
Study Completion Date
February 28, 2009
Allogeneic stem cell transplant
Participants will receive a reduced intensity conditioning regimen consisting of fludarabine, thiotepa, melphalan, and OKT3 followed by an infusion of haploidentical stem cells. Rituximab will be administered within 24 hours of the infusion in an effort to prevent posttransplant lymphoproliferative disorder LPD. In addition to T-cell depletion of the donor product, participant will receive mycophenolate mofetil for prophylaxis of GVHD.
St. Jude Children's Research Hospital, Memphis
St. Jude Children's Research Hospital
OTHER