150
Participants
Start Date
August 31, 2005
Primary Completion Date
May 31, 2011
Study Completion Date
May 31, 2011
Allopurinol
Allopurinol (300 mg capsule) was given for 8-10 weeks compared to placebo group after initial baseline testing. After two weeks on the Allopurinol, a serum uric acid level was obtained. If the uric acid level was greater than 5.5, the Allopurinol dosage was increased to 600mg (two 300 mg capsules)for the duration of the trial, 6-8 weeks.
Placebo
Placebo capsule (matched in appearance for Allopurinol and labeled 300mg) was given for 8-10 weeks compared to the Allopurinol group after initial baseline testing. After two weeks on the placebo, a serum uric acid level was obtained. If the uric acid level was greater than 5.5, the placebo dosage was increased to 600mg (two 300 mg capsules)for the duration of the study, 6-8 weeks.
Chlorthalidone
Chlorthalidone 25 mg was given daily for 5 weeks before baseline visit for testing and continued through out the study.
Potassium chloride
Potassium Chloride 40-50meq was given daily for 5 weeks before baseline visit for testing and continued through out the study.
University of Florida, Gainesville
University of Florida
OTHER