Phase II Docetaxel / Carboplatin / XRT + Surgical Resection in Stage III NSCLC

PHASE2TerminatedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

March 31, 2003

Primary Completion Date

September 30, 2009

Study Completion Date

November 30, 2014

Conditions
Lung CancerCarcinoma, Non-Small-Cell Lung
Interventions
DRUG

Docetaxel

20 mg/m2, 75 mg/m2 infusion

DRUG

Carboplatin

AUC of 2 and 6 infusion

PROCEDURE

Radiation therapy

NEOADJUVANT RADIOTHERAPY Radiation therapy will be concurrent with the chemotherapy. Radiation therapy will begin within 24 hours of chemotherapy. CONSOLIDATION RADIOTHERAPY Patients with positive surgical margins or incomplete resection (tumor shaved from spine or great vessels) will receive an additional boost of radiotherapy 3 to 6 weeks after surgery. This will be a 16 Gy boost given with concurrent weekly chemotherapy as during the neoadjuvant period.

PROCEDURE

Surgical resection

All patients will be taken to surgical excision, unless they have developed a condition other than progressive disease, which would make surgery unsafe.

Trial Locations (1)

94305

Stanford University School of Medicine, Stanford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Aventis Pharmaceuticals

INDUSTRY

lead

Stanford University

OTHER