Busulfan, Melphalan, and Thiotepa in Treating Patients Who Are Undergoing an Autologous Stem Cell Transplant for Hodgkin's or Non-Hodgkin's Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

March 31, 2005

Primary Completion Date

August 31, 2015

Study Completion Date

December 31, 2016

Conditions
Lymphoma
Interventions
BIOLOGICAL

filgrastim

5mcg/kg IVPB will be administered beginning on day +5 and continued until ANC\> 1500 for 2 consecutive days.

DRUG

busulfan

3.2mg/kg/day for 3 days starting on day -8. Each dose of intravenous busulfan will be mixed in a concentration of 0.54 mg/ml of 0.9% saline and infused over 3 hours.

DRUG

melphalan

50mg/m2/day/iv, infused over 30 minutes on days -5 and -4. The reconstituted melphalan is diluted in 250cc normal saline to a concentration not greater than 0.4 mg/ml.

DRUG

thiotepa

250 mg/m2/day/iv on days -3 and -2

PROCEDURE

bone marrow ablation with stem cell support

The transplant therapy should begin within 2 weeks of registration, but no sooner then 30 days after the last dose of chemotherapy.

PROCEDURE

peripheral blood stem cell transplantation

Performed 36-48 hours following last chemotherapy dose.

Trial Locations (1)

97239-3098

Knight Cancer Institute at Oregon Health and Science University, Portland

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

OHSU Knight Cancer Institute

OTHER

NCT00238433 - Busulfan, Melphalan, and Thiotepa in Treating Patients Who Are Undergoing an Autologous Stem Cell Transplant for Hodgkin's or Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter