37
Participants
Start Date
March 31, 2005
Primary Completion Date
August 31, 2015
Study Completion Date
December 31, 2016
filgrastim
5mcg/kg IVPB will be administered beginning on day +5 and continued until ANC\> 1500 for 2 consecutive days.
busulfan
3.2mg/kg/day for 3 days starting on day -8. Each dose of intravenous busulfan will be mixed in a concentration of 0.54 mg/ml of 0.9% saline and infused over 3 hours.
melphalan
50mg/m2/day/iv, infused over 30 minutes on days -5 and -4. The reconstituted melphalan is diluted in 250cc normal saline to a concentration not greater than 0.4 mg/ml.
thiotepa
250 mg/m2/day/iv on days -3 and -2
bone marrow ablation with stem cell support
The transplant therapy should begin within 2 weeks of registration, but no sooner then 30 days after the last dose of chemotherapy.
peripheral blood stem cell transplantation
Performed 36-48 hours following last chemotherapy dose.
Knight Cancer Institute at Oregon Health and Science University, Portland
National Cancer Institute (NCI)
NIH
OHSU Knight Cancer Institute
OTHER