1,316
Participants
Start Date
February 28, 2005
Primary Completion Date
February 28, 2009
Study Completion Date
August 31, 2016
Surfactant
Intubation and administration of surfactant by 1 hour of age.
Continuous Positive Airway Pressure (CPAP)
Continuous Positive Airway Pressure/Positive End Expiratory Pressure (CPAP/PEEP) begun in the delivery room and continuing in the NICU
Supplemental oxygen with target saturation of 85 to 89%
Supplemental oxygen in the range of 85% to 89% until the infant is no longer requiring ventilatory support or oxygen
Supplemental oxygen with target saturation of 91 to 95%
Supplemental oxygen in the range of 91% to 95% until the infant is no longer requiring ventilatory support or oxygen.
University of Rochester, Rochester
Wake Forest University, Charlotte
RTI International, Durham
Duke University, Durham
Emory University, Atlanta
University of Miami, Miami
University of Alabama at Birmingham, Birmingham
University of Tennessee, Memphis
Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland
Cincinnati Children's Medical Center, Cincinnati
Indiana University, Indianapolis
Wayne State University, Detroit
University of Iowa, Iowa City
University of Texas Southwestern Medical Center at Dallas, Dallas
University of Texas Health Science Center at Houston, Houston
University of Utah, Salt Lake City
University of New Mexico, Albuquerque
Stanford University, Palo Alto
University of California at San Diego, San Diego
Yale University, New Haven
Tufts Medical Center, Boston
Brown University, Women & Infants Hospital of Rhode Island, Providence
National Heart, Lung, and Blood Institute (NHLBI)
NIH
National Center for Research Resources (NCRR)
NIH
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
NICHD Neonatal Research Network
NETWORK