Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients

PHASE3CompletedINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

January 31, 1998

Primary Completion Date

July 31, 2007

Study Completion Date

January 31, 2010

Conditions
ChildrenChronic Renal FailureHypertensionAcquired Kidney DiseaseCongenital Kidney Disease
Interventions
DRUG

ACE Inhibition

ACE inhibitor ramipril (6 mg/m²/day) will be given to all subjects.

DRUG

Intensified Blood Pressure Control

Any antihypertensive drugs except ACE inhibitors and angiotensin receptor blockers will be allowed.

DRUG

Add-on Angiotensin Receptor Blockade

In patients who show persistent or breakthrough proteinuria at the end of the initial study period, telmisartan (50 mg/m²/day) will be added to the existing medication.

Trial Locations (33)

1083

Semmelweis University Budapest, 1st Department of Pediatrics, Budapest

2600

Vilnius University Children's Hospital, Pediatric Department, Nephrology Unit, Vilnius

8032

University Children's Hospital, Nephrology Unit, Zurich

10126

Ospedale Infantile Regina Margherita, U.O.A. Nefrologia, Dialisi, Trapianto, Torino

11000

Faculty of Medicine Belgrade, University Children's Hospital, Nephrology Unit, Belgrade

13353

Humboldt University Berlin, Charité Children's Hospital, Department of Pediatric Nephrology, Berlin

14186

Karolinska Institute, Huddinge University Hospital, Dept. of Pediatrics, Stockholm

16148

G.Gaslini Institute, Nephrology Unit, Genoa

18050

University Children's Hospital, Dept. of Nephrology, Rostock

20122

Azienda Ospedaliera, Istitui Clinici di Perfezionamento, Servizio die Emodialisi Pediatrica, Milan

20246

University Hospital Hamburg-Eppendorf, University Children's Hospital, Dept. of Pediatric Nephrology, Hamburg

30623

Hannover Medical School, Children's Hospital Div. II, Pediatric Nephrology, Hanover

34303

Istanbul University, Cerrahpasa Medical Faculty, Dept, of Pediatrics, Istanbul

34390

University of Istanbul, Istanbul Medical Faculty, Dept. of Pediatrics, Istanbul

35037

Philipps University Marburg, Dept. of Pediatrics, Marburg

35100

Ege University Medical Faculty, Dept. of Pediatric Nephrology, Izmir

35128

Azienda Ospedaliera die Padova. U.O. Nefrologia Dialisi e Trapianto - Dipartimento di Pediatria, Padua

45122

University Hospital Essen, Department of Pediatrics, Pediatric Nephrology Unit, Essen

55131

Johannes Gutenberg University Mainz, Department of Pediatrics,, Mainz

67098

Hopiteaux Universitaires de Strasbourg, Strasbourg

69120

Division of Pediatric Nephrology, Children's Hospital, University of Heidelberg, Heidelberg

75015

Hopital Necker, Division of Pediatric Nephrology, Paris

Inserm U574, Paris

150 18

University Hospital Motol, 1st Department of Pediatrics, Prague

04129

Urban Hospital St. Georg, Department of Pediatrics, Pediatric Nephrology Unit, Leipzig

00165

Ospedale Pediatrico Bambino Gesù, Division of Nephrology and Dialysis, Rome

80-211

Medical University of Gdansk, Pediatric Nephrology Department, Gdansk

30-663

Jagellonian University Medical College, Department of Pediatric Nephrology, Krakow

71-344

Clinic of Pediatrics, Pomeranian Academy of Medicine, Szczecin

04-736

Children's Memorial Health Hospital, Nephrology and Kidney Transplantation Department, Warsaw

4202 - 451

Hospital S. Joao-Faculade de Medicina do Porto, Dept. of Pediatrics, Porto

01330

Cukurova University School of Medicine, Dept. of Pediatric Nephrology, Adana

06100

Hacettepe University, Faculty of Medicine, Pediatric Nephrology and Rheumatology, Ankara

All Listed Sponsors
collaborator

European Commission

OTHER

collaborator

Boehringer Ingelheim

INDUSTRY

collaborator

Baxter Healthcare Corporation

INDUSTRY

collaborator

Aventis Pharmaceuticals

INDUSTRY

lead

Heidelberg University

OTHER