Pemetrexed as Second-Line Therapy in Treating Patients With Hormone Refractory Prostate Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

March 31, 2009

Study Completion Date

March 31, 2009

Conditions
Prostate Cancer
Interventions
DRUG

Pemetrexed

Pemetrexed 500 mg/m2 IV over 10 minutes, day 1 of 21-day cycle

DIETARY_SUPPLEMENT

Folic Acid

All participants received oral Folic Acid 350-100ug once per day for 7 days preceding the first pemetrexed dose and continuing throughout the study and and for 21 days after the last dose of pemetrexed.

DIETARY_SUPPLEMENT

Vitamin B12

All patients received vitamin B12 1000ug intramuscular injection the week preceding the first pemetrexed dose and received additional 1000ug intramuscular injections every three cycles thereafter on the same day of pemetrexed administration.

Trial Locations (15)

19026

Consultants in Medical Oncology & Hematology, Drexel Hill

19106

Pennsylvania Oncology-Hematology Associates, Philadelphia

46202

Indiana University Cancer Center, Indianapolis

Quality Cancer Center (MCGOP), Indianapolis

46256

Community Regional Cancer Center, Indianapolis

46515

Elkhart Clinic, Elkhart

46601

Northern Indiana Cancer Research Consortium, South Bend

46815

Fort Wayne Oncology & Hematology, Inc, Fort Wayne

47303

Medical Consultants, P.C., Muncie

47804

AP&S Clinic, Terre Haute

47904

Arnett Cancer Care, Lafayette

49201

Center for Hematology/Oncology of S. Michigan, Jackson

61401

Medical & Surgical Specialists, LLC, Galesburg

68114

Methodist Cancer Center, Omaha

08060

Hematology Oncology Associates S.J., P.A., Mount Holly

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Walther Cancer Institute

OTHER

lead

Christopher Sweeney, MBBS

OTHER

NCT00216099 - Pemetrexed as Second-Line Therapy in Treating Patients With Hormone Refractory Prostate Cancer | Biotech Hunter | Biotech Hunter