Alemtuzumab to Treat Severe Aplastic Anemia

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

September 15, 2005

Primary Completion Date

April 14, 2014

Study Completion Date

October 15, 2018

Conditions
Severe Aplastic Anemia, RefractorySevere Aplastic Anemia, Relapse
Interventions
BIOLOGICAL

Alemtuzumab (Campath )

Campath administered at a dose of 10/mg/day for 10 days

DRUG

Cyclosporine

Subjects who relapse after initial response to alemtuzumab therapy will have cyclosporine added to the regimen after the 6 month visit. Dosing will be based on ideal body weight and will be adjusted to maintain a target level of 200 - 400 ng /ml.

Trial Locations (1)

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

All Listed Sponsors
lead

National Heart, Lung, and Blood Institute (NHLBI)

NIH

NCT00195624 - Alemtuzumab to Treat Severe Aplastic Anemia | Biotech Hunter | Biotech Hunter