Treatment of Mania Symptoms With Drug Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

November 30, 2010

Study Completion Date

November 30, 2010

Conditions
Bipolar DisorderSchizophrenia
Interventions
DRUG

Divalproex-extended release (DVP-ER)

Divalproex ER will be given in 250 mg or 500 mg tablets. Dosing is once a day, every day, for the duration of study participation, either 12 or 26 weeks.

DRUG

Lithium

Extended release lithium will be provided in 300 mg capsules. Participants will be dosed to a therapeutic blood level of lithium from 0.8 to 1.2 mcg/L.

DRUG

Quetiapine

Quetiapine will be dosed to efficacy, provided in 50 mg, 100 mg, 200 mg, or 300 mg pills.

Trial Locations (1)

94304

VA Palo Alto Health Care System, Palo Alto

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Palo Alto Veterans Institute for Research

OTHER

NCT00183443 - Treatment of Mania Symptoms With Drug Therapy | Biotech Hunter | Biotech Hunter