Radiation Therapy or Temozolomide in Treating Patients With Gliomas

PHASE3CompletedINTERVENTIONAL
Enrollment

709

Participants

Timeline

Start Date

July 31, 2005

Primary Completion Date

August 31, 2013

Study Completion Date

May 31, 2014

Conditions
Brain and Central Nervous System Tumors
Interventions
DRUG

temozolomide

Temozolomide 75 mg/m2 daily x 21 days, q 28 days until progression or for max. 12 cycles

RADIATION

radiation therapy

50.4 Gy, standard fractionation (28 x 1.8 Gy), conformal techniques

Trial Locations (89)

1011

Centre Hospitalier Universitaire Vaudois - Lausanne, Lausanne

1070

Hopital Universitaire Erasme, Brussels

1090

Medical University Vienna - General Hospital AKH, Vienna

Universitair Ziekenhuis Brussel, Brussels

1145

National Institute Of Neurosurgery, Budapest

2031

Prince of Wales Private Hospital, Randwick

2050

Sydney Cancer Centre at Royal Prince Alfred Hospital, Sydney

2065

Royal North Shore Hospital, St Leonards

2298

Calvary Mater Newcastle, Waratah

3000

U.Z. Leuven - Campus Gasthuisberg, Leuven

3002

Peter MacCallum Cancer Centre, East Melbourne

3084

Austin and Repatriation Medical Centre, Heidelberg West

3181

Alfred Hospital, Prahran

4029

Royal Brisbane and Women's Hospital, Brisbane

4101

Mater Adult Hospital, South Brisbane

4102

Princess Alexandra Hospital, Brisbane

4240

Centre Francois Baclesse, Esch / Alzette

6009

Sir Charles Gairdner Hospital - Nedlands, Nedlands

6500

Oncology Institute of Southern Switzerland - Ospedale Regionale Bellinzona e Valli, Bellinzona

8091

UniversitaetsSpital Zurich, Zurich

10126

Azienda Sanitaria Ospedale San Giovanni Battista Molinette di Torino, Turin

13385

CHU de la Timone, Marseille

17007

ICO Girona - Hospital Doctor Josep Trueta (Institut Catala D'Oncologia), Girona

20132

Ospedale San Raffaele, Milan

31059

Institut Claudius Regaud, Toulouse

31096

Rambam Health Care Campus, Oncology Institute, Haifa

33075

CHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre, Bordeaux

33076

Institut Bergonie, Bordeaux

35042

Centre Eugene Marquis, Rennes

38043

CHU de Grenoble - Hopital de la Tronche, Grenoble

44805

Centre Regional Rene Gauducheau, Nantes-Saint Herblain

67085

Centre Paul Strauss, Strasbourg

72076

Universitaetsklinikum Tuebingen, Tübingen

75651

Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere, Paris

93053

Universitaetskliniken Regensburg, Regensburg

94805

Gustave Roussy, Villejuif

119228

National University of Singapore, Singapore

BC NSW 1871

Liverpool Hospital, Liverpool

T2N 4N2

Tom Baker Cancer Centre - Calgary, Calgary

R3E 0V9

CancerCare Manitoba, Winnipeg

E2L 4L2

Saint John Regional Hospital, Saint John

B3H 1V7

Nova Scotia Cancer Centre, Halifax

L8V 5C2

Margaret and Charles Juravinski Cancer Centre, Hamilton

N6A 4L6

London Regional Cancer Program at London Health Sciences Centre, London

M4N 3M5

Edmond Odette Cancer Centre at Sunnybrook, Toronto

M5G 2M9

Princess Margaret Hospital, Toronto

H2L 4M1

Hopital Notre-Dame du CHUM, Montreal

H2W 1S6

Mcgill University Health Centre - Gerald Bronfman Centre - Dept Of Oncology, Montreal

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

V5Z4E9

BC Cancer Agency, Vancouver

Unknown

National Cancer Institute of Egypt, Cairo

Canterbury Health Laboratories, Christchurch

D-69120

Universitatsklinikum Heidelberg, Heidelberg

04103

Universitaetsklinikum Leipzig, Leipzig

I-40139

Ospedale Bellaria, Bologna

00144

Istituto Regina Elena / Istituti Fisioterapici Ospitalieri, Roma

1007MB

Vrije Universiteit Medisch Centrum, Amsterdam

1105 AZ

Academisch Medisch Centrum - Universiteit van Amsterdam, Amsterdam

9713 GZ

University Medical Center Groningen, Groningen

6201 BN

Maastro Clinic - Maastricht Radiation Oncology, Maastricht

6500 HB

Radboud University Medical Center Nijmegen, Nijmegen

3008 AE

Erasmus MC Cancer Institute - location Daniel den Hoed, Rotterdam

2501 CK

Medisch Centrum Haaglanden - Westeinde, The Hague

5042 SB

Dr. Bernard Verbeeten Instituut, Tilburg

1099-023 Codex

Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, SA, Lisbon

08916

ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia), Badalona - (Barcelona)

08035

Hospital General Vall D'Hebron, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

Hospital Clinico Universitario de Barcelona, Barcelona

08907

ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia), L'Hospitalet de Llobregat

S-581 85

University Hospital of Linkoping, Linköping

SE-22185

Skane University Hospital, Lund

SE-901 87

Umea Universitet, Umeå

SE-75185

Uppsala University Hospital, Uppsala

BS2 8ED

University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre, Bristol

CH63 4JY

Clatterbridge Centre for Oncology, Bebington, Wirral

CB2 0QQ

Addenbrooke's Hospital, Cambridge

LS9 7TF

Leeds Cancer Centre at St. James's University Hospital, Leeds

NW1 2PG

University College Hospital, London

SW3 6JJ

Royal Marsden - London, London

M20 4BX

Christie Hospital, Manchester

TS4 3BW

James Cook University Hospital, Middlesbrough

S10 2SJ

Cancer Research Centre at Weston Park Hospital, Sheffield

SM2 5PT

Royal Marsden - Surrey, Sutton

GL53 7AN

Gloucestershire Hospital NHS Foundation Trust - Cheltenham General Hospital, Cheltenham

EH4 2XU

Western General Hospital, Edinburgh

NW3 2QG

Royal Free Hospital, London

OX3 7LE

Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford

PR2 9HT

Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital, Preston

Sponsors
All Listed Sponsors
collaborator

NCIC Clinical Trials Group

NETWORK

collaborator

British Medical Research Council

OTHER_GOV

collaborator

Trans Tasman Radiation Oncology Group

OTHER

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK