Clozapine Versus Haloperidol for Treating the First Episode of Schizophrenia

PHASE4TerminatedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

March 31, 1996

Primary Completion Date

September 30, 2003

Study Completion Date

October 31, 2003

Conditions
Schizophrenia
Interventions
DRUG

Clozapine

Medication will be divided into twice daily dosing and administered in a blinded fashion. The medication will be tapered from 12.5 mg on Day 1 to up to 300 mg on Day 12.

DRUG

Haloperidol

Medication will be divided into twice daily dosing and administered in a blinded fashion. The medication will be tapered from 2 mg on Day 1 to up to 12 mg on Day 12.

Trial Locations (1)

02130

Commonwealth Research Center, Jamaica Plain

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

collaborator

Dartmouth-Hitchcock Medical Center

OTHER

collaborator

Commonwealth Research Center, Massachusetts

OTHER

collaborator

Novartis

INDUSTRY

lead

Harvard Medical School (HMS and HSDM)

OTHER