114
Participants
Start Date
October 31, 2004
Primary Completion Date
March 31, 2008
Study Completion Date
March 31, 2008
Metformin
Medication was initiated in a step-up fashion every five days, from one tablet per day to four (500 mg per tablet).
Placebo
Placebo
Lifestyle Intervention
A combined intervention of diet and exercise was employed with the goal of achieving an average weight loss of at least 7% of initial body weight over six months with a prescription of 150 min/week of exercise combined with a low-calorie diet.
Penn State Milton S. Hershey Medical Center, Hershey
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Milton S. Hershey Medical Center
OTHER