Pharmacogenetics of Disulfiram for Cocaine

Disulfiram 250 mg/day by mouth daily during study weeks 2-13. Disulfiram discontinued during study weeks 14-15.

Initial dose 25 mg; increased by 5 mg at each subsequent daily dosing until 60 mg maintenace dose reached.

1-hour weekly, individual, manual-guided Cognitive Behaviorial Therapy.

Lactose was added to both the active disulfiram and placebo doses so they tasted identical.