Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis

PHASE2CompletedINTERVENTIONAL
Enrollment

143

Participants

Timeline

Start Date

May 31, 2005

Primary Completion Date

April 30, 2008

Study Completion Date

April 30, 2008

Conditions
Cryptococcal Meningitis
Interventions
DRUG

Amphotericin B

Amphotericin B 0.7 mg/kg IV for the first 14 days of treatment. This period may be extended up to an additional 7 days.

DRUG

Fluconazole

Fluconazole 400 or 800 mg daily. Among subjects whose baseline weight is less than 40 kg, randomized fluconazole doses will be 200 mg/kg daily or 400 mg/kg daily.

Trial Locations (15)

10400

Ramathibodi Hospital, Mahidol University, Bangkok

10700

Mahidol University - Siriraj Hospital - Medicine, Bangkok

11000

Bamrasnaradura Institution, Nonthaburi

32610

University of Florida, Gainesville

35255

University of Alabama at Birmingham, Birmingham

40002

Khon Kaen University, Khon Kaen

48201

Harper University Hospital, Detroit

50200

Chiang Mai University, Chiang Mai

70112

Tulane University Health Sciences Center, New Orleans

77030

Texas Medical Center - Michael E. DeBakey Veterans Affairs, Houston

The University of Texas Health Science Center at Houston, Houston

90033

University of Southern California, Los Angeles

90502

Harbor-UCLA Medical Center, Los Angeles

80291-0238

University of Colorado, Denver

33136-1096

University of Miami, Miami

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00145249 - Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis | Biotech Hunter | Biotech Hunter