1,334
Participants
Start Date
November 14, 2005
Primary Completion Date
January 31, 2015
Study Completion Date
September 30, 2022
Cisplatin
Given IV
Doxorubicin Hydrochloride
Given IV
Etoposide
Given IV
Ifosfamide
Given IV
Methotrexate
Given IV
Peginterferon Alfa-2b
Given subcutaneously
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Therapeutic Conventional Surgery
Undergo amputation or limb salvage surgery
Swiss Pediatric Oncology Group - Lausanne, Lausanne
Starship Children's Hospital, Grafton
Swiss Pediatric Oncology Group - Geneva, Geneva
The Children's Hospital at Westmead, Westmead
Westmead Hospital, Westmead
John Hunter Children's Hospital, Newcastle
Swiss Pediatric Oncology Group - Bern, Bern
Royal Children's Hospital, Parkville
Royal Brisbane and Women's Hospital, Herston
Royal Children's Hospital-Brisbane, Herston
Queensland Children's Hospital, South Brisbane
Women's and Children's Hospital-Adelaide, North Adelaide
Wellington Children's Hospital, Wellington
Princess Margaret Hospital for Children, Perth
Christchurch Hospital, Christchurch
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Brooklyn Hospital Center, Brooklyn
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
Virginia Commonwealth University/Massey Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Charleston Division, Charleston
Cabell-Huntington Hospital, Huntington
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
East Carolina University, Greenville
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Medical University of South Carolina, Charleston
BI-LO Charities Children's Cancer Center, Greenville
Greenville Cancer Treatment Center, Greenville
Children's Healthcare of Atlanta - Egleston, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
Sacred Heart Hospital, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Clinic - Orlando, Orlando
UF Cancer Center at Orlando Health, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Miami Cancer Institute, Miami
Broward Health Medical Center, Fort Lauderdale
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Lee Memorial Health System, Fort Myers
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
University of Alabama at Birmingham Cancer Center, Birmingham
Vanderbilt University/Ingram Cancer Center, Nashville
T C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Mercy Children's Hospital, Toledo
University of Toledo, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
Riley Hospital for Children, Indianapolis
Saint Vincent Hospital and Health Care Center, Indianapolis
Beaumont Children's Hospital-Royal Oak, Royal Oak
William Beaumont Hospital-Royal Oak, Royal Oak
C S Mott Children's Hospital, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Ascension Saint John Hospital, Detroit
Hurley Medical Center, Flint
Bronson Methodist Hospital, Kalamazoo
Kalamazoo Center for Medical Studies, Kalamazoo
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids
Spectrum Health at Butterworth Campus, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Hospital and Clinics, Madison
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Loyola University Medical Center, Maywood
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Lurie Children's Hospital-Chicago, Chicago
Rush University Medical Center, Chicago
University of Illinois, Chicago
Saint Jude Midwest Affiliate, Peoria
Southern Illinois University School of Medicine, Springfield
Cardinal Glennon Children's Medical Center, St Louis
Washington University School of Medicine, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
University of Kansas Cancer Center, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Tulane University Health Sciences Center, New Orleans
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Scott and White Memorial Hospital, Temple
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
M D Anderson Cancer Center, Houston
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Texas Tech University Health Sciences Center-Amarillo, Amarillo
Children's Hospital Colorado, Aurora
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner University Medical Center - Tucson, Tucson
University of New Mexico Cancer Center, Albuquerque
Nevada Cancer Research Foundation CCOP, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Children's Hospital Los Angeles, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Mattel Children's Hospital UCLA, Los Angeles
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Harbor-University of California at Los Angeles Medical Center, Torrance
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Mount Zion, San Francisco
UCSF Medical Center-Parnassus, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
University of Hawaii Cancer Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Tripler Army Medical Center, Honolulu
Legacy Emanuel Children's Hospital, Portland
Legacy Emanuel Hospital and Health Center, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Mary Bridge Children's Hospital and Health Center, Tacoma
Madigan Army Medical Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Arkansas Children's Hospital, Little Rock
Children's Hospital and Research Center at Oakland, Oakland
University of Connecticut, Farmington
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
UMass Memorial Medical Center - University Campus, Worcester
Michigan State University Clinical Center, East Lansing
Hackensack University Medical Center, Hackensack
Saint Barnabas Medical Center, Livingston
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Overlook Hospital, Summit
Penn State Milton S Hershey Medical Center, Hershey
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Vermont and State Agricultural College, Burlington
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
Children's Hospital, London
Victoria Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Saskatoon Cancer Centre, Saskatoon
Centre Hospitalier Universitaire de Quebec, Québec
San Jorge Children's Hospital, San Juan
Collaborators (1)
National Cancer Institute (NCI)
NIH
University College, London
OTHER
Medical Research Council
OTHER_GOV
Children's Oncology Group
NETWORK