Study of Intra-articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

August 31, 2005

Primary Completion Date

October 31, 2008

Study Completion Date

May 31, 2009

Conditions
Arthritis, RheumatoidArthritis, PsoriaticAnkylosing Spondylitis
Interventions
GENETIC

tgAAC94 gene therapy vector

Single Dose 1x10\^11 DRP/mL

GENETIC

tgAAC94 gene therapy vector

Second dose of 1x10\^11 DRP/mL tgAAC94 administered once target joint reaches predetermined criteria for re-injection (on or after Week 12) at the same concentration as initial dose.

GENETIC

tgAAC94 placebo

placebo

GENETIC

tgAAC94 gene therapy vector

Single Dose 1x10\^12 DRP/mL tgAAC94

GENETIC

tgAAC94 gene therapy vector

Second dose of 1x10\^12 DRP/mL tgAAC94 administered once target joint reaches predetermined criteria for re-injection (on or after Week 12) at the same concentration as initial dose.

GENETIC

tgAAC94 gene therapy vector

Single Dose 1x10\^13 DRP/mL tgAAC94

GENETIC

tgAAC94 gene therapy vector

Second dose of 1x10\^13 DRP/mL tgAAC94 administered once target joint reaches predetermined criteria for re-injection (on or after Week 12) at the same concentration as initial dose.

Trial Locations (22)

13790

United Medical Associates, Johnson City

16635

Altoona Center for Clinical Research, Duncansville

19090

Rheumatic Disease Associates, Willow Grove

21702

Arthritis and Osteoporosis Center of Maryland, Frederick

33486

RASF-Clinical Research Center, Boca Raton

34474

Ocala Rheumatology Research Center, Ocala

34996

Radiant Research Stuart, Stuart

60611

Northwestern Center for Clinical Research, Chicago

62704

The Arthritis Center, Springfield

73103

Bone and Joint Hospital Research Dept., Oklahoma City

75231

Arthritis Consultation Center, Dallas

75235

Metroplex Clinical Research Center, Dallas

78217

Radiant Research San Antonio Northeast, San Antonio

78705

Austin Rheumatology Research, Austin

80230

Denver Arthritis Research Center, Denver

83814

Coeur d'Alene Arthritis Clinic, Coeur d'Alene

85308

Sun Valley Arthritis Center, Glendale

85704

Catalina Pointe Clinical Research, Inc, Tuscon

89502

Arthritis Center of Reno, Reno

91786

Boling Clinical Trials, Upland

92260

Desert Medical Advances, Palm Desert

98104

Seattle Rheumatology Associates, PLLC, Seattle

All Listed Sponsors
lead

Targeted Genetics Corporation

INDUSTRY

NCT00126724 - Study of Intra-articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects | Biotech Hunter | Biotech Hunter