Efficacy of 400 Mg Versus 800 Mg Imatinib in Chronic Myeloid Leukemia in Chronic Phase Patients - TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity)

PHASE3TerminatedINTERVENTIONAL
Enrollment

476

Participants

Timeline

Start Date

June 30, 2005

Primary Completion Date

November 30, 2010

Study Completion Date

November 30, 2010

Conditions
Leukemia, Myeloid, Chronic Phase
Interventions
DRUG

Imatinib mesylate

Imatinib is packaged in bottles as 100mg and 400mg tablets

Trial Locations (75)

14263

Roswell Park Cancer Institute, Buffalo

15224

Western Pennsylvania Hospital, Pittsburgh

15232

University of Pittsburg, Hillman Cancer Center, Pittsburgh

21229

St. Agnes Hospital, Baltimore

22908

University of Virgina Cancer Center, UVA Division of Hematology & Oncology, Charlottesville

27157

Wake Forest University Health Sciences, Winston-Salem

27710

Duke University Medical Center, Durham

29425

MUSC Hollings Cancer Center, Charleston

29615

Cancer Center of the Carolinas, Greenville

Cancer Center of the Carolinas, Greenville

Cancer Centers of the Carolinas, Greenville

32073

Integrated Community Oncology Network, Orange Park

32501

Hematology-Oncology Associates, P.A., Pensacola

32901

Osler Medical Inc., Melbourne

33176

Advanced Medical Specialists, Miami

33401

Palm Beach Cancer Institute, West Palm Beach

36693

University of South Alabama, Mobile

37203

Sarah Cannon Research Institute, Nashville

38138

The Jones Clinic, Germantown

40202

Lousville Oncology, Clinical Research Program M-25, Louisville

40536

University of Kentucky - C201 Clinic, Lexington

University of Kentucky, Lexington

44106

University Hospitals of Cleveland, Case Comprehensive Cancer Center, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

46107

Indiana Blood and Marrow Institutw, Beech Grove

Indiana Blood and Marrow Transplant, Beech Grove

48910

Great Lakes Cancer Institute, Lansing

52242

University of Iowa Hospitals & Clinic, Iowa City

55455

U of Minnesota, Minneapolis

University of Minnesota, Minneapolis

60612

Rush University Medical Center, Chicago

70006

Jayne S. Gurtler, MD, Laura A. Brinz, MD & Angelo Russo, MD, Metairie

70115

Hematology and Oncology Specialists, New Orleans

71103

LSU Health Science Center, Shreveport

71130

LSU Health Scine Center, Shreveport

75390

UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Dallas

77030

MD Anderson Cancer Center, Houston

80218

Rocky Mountain Cancer Center, Denver

87401

San Juan Oncology Associates, Farmington

90095

UCLA Medical Center, Los Angeles

94704

Alta Bates Comprehsenive Cancer Center, Berkeley

University of Miami, Berkeley

95008

South Bay Oncology Hematology Partners, Campbell

96813

Cancer Research Center of Hawaii, Honolulu

97227

Kaiser Permanente Northwest Region Oncology/Hemacology, Portland

Kaiser Permanente Northwest Region, Portland

233401

Palm Beach Cancer Institute, West Palm Beach

07601

Cancer Center at Hackensack University Medical Center, Hackensack

Hackensack University Medical Center, Hackensack

77030-4009

University of Texas / MD Anderson Cancer Center, Houston

Unknown

Novartis Investigative Site, Buenos Aires

Novartis Investigative Site, La Plata

Novartis Investigative Site, St Leonards

Novartis Investigative Site, Waratah

Novartis Investigative Site, Westmead

Novartis Investigative Site, Herston

Novartis Investigative Site, Woolloongabba

Novartis Investigative Site, Adelaide

Novartis Investigative Site, East Melbourne

Novartis Investigative Site, Fitzroy

Novartis Investigative Site, Frankston

Novartis Investigative Site, Parkville

Novartis Investigative Site, Prahran

Novartis Investigative Site, South Brisbane

Novartis Investigative Site, Campinas

Novartis Investigative Site, Calgary

Novartis Investigative Site, Montreal

Novartis Investigative Site, Ottawa

Novartis Investigative Site, Québec

Novartis Investigative Site, Bologna

Novartis Investigative Site, Florence

Novartis Investigative Site, Milan

Novartis Investigative Site, Napoli

Novartis Investigative Site, Orbassano

Novartis Investigative Site, Roma

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY