271
Participants
Start Date
February 28, 2005
Primary Completion Date
April 30, 2008
Study Completion Date
December 31, 2008
Amitriptyline
Amitriptyline will be titrated over a 6-week period as tolerated, to a maximum dose of 75mg. During the 6-week titration period, the patient who cannot tolerate a scheduled increased dose may adjust the medication dose for tolerance by tapering down one 25mg tablet.
Placebo
Placebo will be dosed exactly as active arm.
University of Rochester Medical Center, Rochester
University of Pennsylvania, Philadelphia
University of Maryland, Baltimore
William Beaumont Hospital, Royal Oak
Henry Ford Hospital, Detroit
University of Iowa Hospitals and Clinic, Iowa City
Loyola University Medical Center, Maywood
Stanford University Medical Center, Stanford
University of Washington, Seattle
Queen's University, Kingston
University of Pennsylvania
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH