Remission and Joint Damage Progression in Early Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,052

Participants

Timeline

Start Date

July 31, 2005

Primary Completion Date

February 29, 2008

Study Completion Date

February 28, 2009

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Abatacept

abatacept 10 mg/kg IV monthly, methotrexate weekly, for 24 months

DRUG

placebo

placebo IV, monthly, methotrexate weekly for 12 months followed by abatacept 10 mg/kg IV monthly, methotrexate weekly for 12 months

DRUG

methotrexate

Oral, titrated to at least 15 mg per week not to exceed 20 mg per week administered every 28 days from Month 12 to Month 24

Trial Locations (89)

1070

Local Institution, Brussels

1200

Local Institution, Brussels

2020

Local Institution, Antwerp

3000

Local Institution, Leuven

3144

Local Institution, Malvern

3500

Local Institution, Hasselt

4001

Local Institution, Berea

6008

Local Institution, Shenton Park

7506

Local Institution, Panorama

9317

Local Institution, Bloemfontein

13905

Regional Rheumatology Associates, Binghamton

14059

Local Institution, Berlin

15706

Local Institution, A Coruña

16635

Altoona Center For Clinical Research, Duncansville

20157

Local Institution, Milan

20551

Local Institution, Rio de Janeiro - Rj

21000

Local Institution, Dijon

21502

Osteoporosis And Clinical Trials Center, Cumberland

21740

Malamet & Klein, Md, Pa, Hagerstown

22081

Local Institution, Hamburg

22205

Arthritis Clinic Of Northern Virginia, P.C., Arlington

27834

Physicians East, Pa, Greenville

28210

Carolina Bone & Joint, Charlotte

28625

Carolina Pharmaceutical Research, Statesville

29406

Low Country Research Center, Charleston

31000

Local Institution, Chihuahua City

34295

Local Institution, Montpellier

35801

Rheumatology Associates Of North Alabama, Huntsville

37000

Local Institution, León

39008

Local Institution, Santander

41071

Local Institution, Seville

42650

Local Institution, Guadalajara

44340

Local Institution, Guadalajara

44690

Local Institution, Guadalajara

46227

Diagnostic Rheumatology And Research, Indianapolis

52140

Local Institution, Metepec

58000

Local Institution, Morelia

60055

Local Institution, Jesi(Ancona)

60773

Local Institution, Poznan

62270

Local Institution, Cuernavaca

64020

Local Institution, Monterrey

67098

Local Institution, Strasbourg

68516

Arthritis Center Of Nebraska, Lincoln

73071

Lion Research, Norman

73103

Health Research Of Oklahoma, Oklahoma City

73112

Lynn Health Sciences Institute, Oklahoma City

74043

Local Institution, Goiânia

78240

Local Institution, San Luis Potosí City

78705

Walter F Chase Md Pa, Austin

80060

Local Institution, Curitiba

80910

Arthritis Assoc And Osteo Ctr Of Col Sprgs, Colorado Springs

91610

Local Institution, Porto Alegre

92646

Talbert Medical Group, Huntington Beach

115522

Local Institution, Moscow

119049

Local Institution, Moscow

06611

New England Research Associates, Llc, Trumbull

04039

Local Institution, São Paulo

04230

Local Institution, São Paulo

A1B 3E1

Local Institution, St. John's

N2M 5N6

Local Institution, Kitchener

M5G 1X5

Local Institution, Toronto

H2L 1S6

Local Institution, Montreal

G1V 3M7

Local Institution, Québec

J1H 5N4

Local Institution, Sherbrooke

S7N 0W8

Local Institution, Saskatoon

128 50

Local Institution, Prague

06202

Local Institution, Nice

04103

Local Institution, Leipzig

04229

Local Institution, Leipzig

06700

Local Institution, D.f.

1081 HV

Local Institution, Amsterdam

2300 RC

Local Institution, Leiden

6500 HB

Local Institution, Nijmegen

61-545

Local Institution, Poznan

02-637

Local Institution, Warsaw

00716

Local Institution, Ponce

0002

Local Institution, Muckleneuk

0084

Local Institution, Pretoria

431-070

Local Institution, Anyang

705-718

Local Institution, Daegu

302-799

Local Institution, Daejeon

110-744

Local Institution, Seoul

133-792

Local Institution, Seoul

137-040

Local Institution, Seoul

138-736

Local Institution, Seoul

M13 9WL

Local Institution, Manchester

G12 0YN

Local Institution, Glasgow

LS7 4SA

Local Institution, Leeds

NE1 4LP

Local Institution, Newcastle

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY