Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

109

Participants

Timeline

Start Date

September 30, 2005

Primary Completion Date

March 31, 2009

Study Completion Date

September 30, 2012

Conditions
Lung Cancer
Interventions
BIOLOGICAL

cetuximab

400 mg/sq m IV over 120 min: Day 1; Week 1 250 mg/sq m IV over 60 min weekly for 6 more weeks.

DRUG

carboplatin

AUC = 5 q 21 days for 4 cycles

DRUG

pemetrexed disodium

500 mg/sq m IV q 21 days during chemoradiation and consolidation chemotherapy phases

RADIATION

radiation therapy

Thoracic radiotherapy: 70 Gy for 7 weeks beginning on Day 1.

Trial Locations (71)

10029

Mount Sinai Medical Center, New York

12801

Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls

13057

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse

13210

SUNY Upstate Medical University Hospital, Syracuse

Veterans Affairs Medical Center - Syracuse, Syracuse

19713

CCOP - Christiana Care Health Services, Newark

19958

Tunnell Cancer Center at Beebe Medical Center, Lewes

20016

Sibley Memorial Hospital, Washington D.C.

21014

Upper Chesapeake Medical Center, Bel Air

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21921

Union Hospital Cancer Program at Union Hospital, Elkton MD

24115

Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County, Martinsville

24273

Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton

24541

Danville Regional Medical Center, Danville

25702

St. Mary's Regional Cancer Center at St. Mary's Medical Center, Huntington

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

27710

Duke Comprehensive Cancer Center, Durham

28374

FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst

28501

Kinston Medical Specialists, Kinston

28791

Pardee Memorial Hospital, Hendersonville

28801

Mission Hospitals - Memorial Campus, Asheville

29401

Roper St. Francis Cancer Center at Roper Hospital, Charleston

29501

McLeod Regional Medical Center, Florence

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

46815

Fort Wayne Medical Oncology and Hematology, Fort Wayne

52402

Iowa Blood and Cancer Care, Cedar Rapids

St. Luke's Hospital, Cedar Rapids

52403

Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

60525

La Grange Memorial Hospital, La Grange

60640

Louis A. Weiss Memorial Hospital, Chicago

63017

Saint Luke's Hospital, Chesterfield

63110

Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - Saint Louis, St Louis

63128

St. Anthony's Cancer Center, St Louis

63131

Missouri Baptist Cancer Center, St Louis

63141

Arch Medical Services, Incorporated at Center for Cancer Care and Research, St Louis

65201

Missouri Cancer Associates, Columbia

68803

Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center, Grand Island

69103

Callahan Cancer Center at Great Plains Regional Medical Center, North Platte

73104

Oklahoma University Cancer Institute, Oklahoma City

73120

Cancer Care Associates - Mercy Campus, Oklahoma City

89102

University Medical Center of Southern Nevada, Las Vegas

89106

CCOP - Nevada Cancer Research Foundation, Las Vegas

93420

Arroyo Grande Community Hospital, Arroyo Grande

94545

Saint Rose Hospital, Hayward

94546

Eden Medical Center, Castro Valley

94588

Valley Care Medical Center, Pleasanton

94602

Highland General Hospital, Oakland

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

CCOP - Bay Area Tumor Institute, Oakland

94806

Doctors Medical Center - San Pablo Campus, San Pablo

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

06830

Bendheim Cancer Center at Greenwich Hospital, Greenwich

32803-1273

Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando

31403-3089

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

60637-1470

University of Chicago Cancer Research Center, Chicago

52242-1002

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

02721

Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River

68198-6805

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

03106

New Hampshire Oncology - Hematology, PA - Hooksett, Hooksett

03246

Lakes Region General Hospital, Laconia

03103

Elliot Regional Cancer Center at Elliot Hospital, Manchester

07503

St. Joseph's Hospital and Medical Center, Paterson

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

02903

Rhode Island Hospital Comprehensive Cancer Center, Providence

02906

Miriam Hospital, Providence

05602

Mountainview Medical, Berlin Corners

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

23298-0037

Virginia Commonwealth University Massey Cancer Center, Richmond

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT00117962 - Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter