53
Participants
Start Date
June 15, 2005
Primary Completion Date
August 11, 2016
Study Completion Date
August 11, 2022
Rituximab (R)
Rituximab is given with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin (EPOCH) and bortezomib every 3 weeks for 6 cycles.
EPOCH
EPOCH is given with Rituximab and bortezomib every 3 weeks for 6 cycles.
Bortezomib (B)
Bortezomib is given alone for one cycle.
Bortezomib
Bortezomib is given with EPOCH and rituximab every 6 weeks for 12 cycles.
Bortezomib or observation
At the beginning of Part C, patients are randomized to receive bortezomib maintenance or be observed w/o bortezomib.
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda
National Cancer Institute (NCI)
NIH