Temozolomide and Radiation Therapy in Treating Patients With Gliomas

PHASE2CompletedINTERVENTIONAL
Enrollment

136

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

February 28, 2013

Study Completion Date

May 20, 2022

Conditions
Brain and Central Nervous System Tumors
Interventions
DRUG

Temozolomide

"Concurrent chemoradiotherapy temozolomide given 75 mg/m\^2 daily during radiotherapy for 6 weeks.~Post-Radiation Temozolomide given 150 mg/m2 daily on days 1-5 every 28 days with cycle one beginning 28 days post-radiotherapy. In the absence of grade 3 or 4 adverse events, a single dose escalation to 200 mg/m2/day could be attempted for cycle 2 and, if tolerated, that dose should continue for all subsequent cycles. Cycles were repeated every 28 days (+/- 2 days) for a total of 12 cycles."

RADIATION

Radiation therapy

One treatment of 1.8 Gy given daily, 5 days per week (over 6 weeks) for a total dose of 54.0 Gy.

Trial Locations (47)

19001

Rosenfeld Cancer Center at Abington Memorial Hospital, Abington

19713

CCOP - Christiana Care Health Services, Newark

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21401

DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis

28801

Mission Hospitals - Memorial Campus, Asheville

29303

CCOP - Upstate Carolina, Spartanburg

32073

Integrated Community Oncology Network - Orange Park, Orange Park

32086

Flagler Cancer Center, Saint Augustine

32177

Florida Cancer Center - Palatka, Palatka

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

Integrated Community Oncology Network at Southside Cancer Center, Jacksonville

32224

Mayo Clinic - Jacksonville, Jacksonville

32250

Integrated Community Oncology Network, Jacksonville Beach

32258

Baptist Medical Center South, Jacksonville

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44460

Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem

44691

Cancer Treatment Center, Wooster

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

53226

Medical College of Wisconsin Cancer Center, Milwaukee

54143

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette

54601

Gundersen Lutheran Center for Cancer and Blood, La Crosse

55905

Mayo Clinic Cancer Center, Rochester

57701

Rapid City Regional Hospital, Rapid City

64131

CCOP - Kansas City, Kansas City

68114

Methodist Estabrook Cancer Center, Omaha

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84770

Dixie Regional Medical Center - East Campus, St. George

85013

Arizona Oncology Services Foundation, Phoenix

90089-9181

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles

32610-0232

University of Florida Shands Cancer Center, Gainesville

60637-1470

University of Chicago Cancer Research Center, Chicago

48109-0942

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007-3731

West Michigan Cancer Center, Kalamazoo

48912-1811

Sparrow Regional Cancer Center, Lansing

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

14263-0001

Roswell Park Cancer Institute, Buffalo

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

44710-1799

Aultman Cancer Center at Aultman Hospital, Canton

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

54301-3526

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

53792-6164

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison

H2L 4M1

Hopital Notre-Dame du CHUM, Montreal

H2W 1S6

McGill Cancer Centre at McGill University, Montreal

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK