Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

January 31, 2007

Primary Completion Date

April 30, 2014

Study Completion Date

April 30, 2014

Conditions
NeurotoxicityUnspecified Adult Solid Tumor, Protocol SpecificUnspecified Childhood Solid Tumor, Protocol Specific
Interventions
DRUG

alpha-lipoic acid

Oral two 300 mg ALA sustained release tablets initiated 4 days after last dose of platinum and discontinued 2 days before next scheduled platinum dose, continued for 24 weeks.

OTHER

placebo

Given orally two similar color and sized placebo control tablets three times a day continued for 24 weeks.

Trial Locations (13)

19096

CCOP - Main Line Health, Wynnewood

29615

CCOP - Greenville, Greenville

47905

Horizon Oncology Center, Lafayette

54449

Marshfield Clinic - Marshfield Center, Marshfield

55416

CCOP - Metro-Minnesota, Saint Louis Park

65804

Cancer Research for the Ozarks, Springfield

71301

Cabrini Center for Cancer Care at Christus St. Frances Cabrini Hospital, Alexandria

72913

Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith

76508

CCOP - Scott and White Hospital, Temple

97225

CCOP - Columbia River Oncology Program, Portland

67214-3882

CCOP - Wichita, Wichita

49007-3731

CCOP - Kalamazoo, Kalamazoo

77030-4009

University of Texas M.D. Anderson CCOP Research Base, Houston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER

NCT00112996 - Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer | Biotech Hunter | Biotech Hunter