Aripiprazole in Children and Adolescents With Bipolar I Disorder

PHASE3CompletedINTERVENTIONAL
Enrollment

296

Participants

Timeline

Start Date

March 31, 2005

Primary Completion Date

February 28, 2007

Study Completion Date

February 28, 2007

Conditions
Bipolar Disorder
Interventions
DRUG

Aripiprazole

Treatment Arm 1 (10 mg treatment arm): Aripiprazole 2 mg QD for 2 days, aripiprazole 5 mg QD for 2 days, and aripiprazole 10 mg QD as the target dose starting on Day 5. Subjects remained on the 10 mg dose for the remainder of the treatment period Subjects reached their target dose through a forced titration schedule and proceeded with treatment at their target dose until Week 4. If the subject reached Week 4, he or she continued into the Extension Phase, a 6-month double-blind treatment period, beginning at the same dose taken at the end of the Acute Phase.

DRUG

Aripiprazole

Treatment Arm 2 (30 mg treatment arm): Aripiprazole 2 mg QD for 2 days, aripiprazole 5 mg QD for 2 days, aripiprazole 10 mg QD for 2 days, aripiprazole 15 mg QD for 2 days, aripiprazole 20 mg QD for 2 days, aripiprazole 25 mg QD for 2 days, and aripiprazole 30 mg QD as the target dose starting on Day 13. Subjects remained on the 30 mg dose for the remainder of the treatment period. Subjects reached their target dose through a forced titration schedule and proceeded with treatment at their target dose until Week 4. If the subject reached Week 4, he or she continued into the Extension Phase, a 6-month double-blind treatment period, beginning at the same dose taken at the end of the Acute Phase.

DRUG

placebo

Placebo tablet

Trial Locations (53)

Unknown

Local Institution, Scottsdale

Local Institution, Little Rock

Local Institution, National City

Local Institution, Orange

Local Institution, Pasadena

Local Institution, Sacramento

Local Institution, San Diego

Local Institution, Stanford

Local Institution, Washington D.C.

Local Institution, Altamonte Springs

Local Institution, Hialeah

Local Institution, Jacksonville

Local Institution, Miami

Local Institution, North Miami

Local Institution, Tampa

Local Institution, Atlanta

Local Institution, Smyrna

Local Institution, Boise

Local Institution, Chicago

Local Institution, Libertyville

Local Institution, Indianapolis

Local Institution, Kansas City

Local Institution, Newton

Local Institution, Lexington

Local Institution, Baton Rouge

Local Institution, Lake Charles

Local Institution, Shreveport

Local Institution, Cambridge

Local Institution, Medford

Local Institution, Clinton Township

Local Institution, Rochester Hills

Local Institution, Kansas City

Local Institution, St Louis

Local Institution, Las Vegas

Local Institution, Elmsford

Local Institution, New York

Local Institution, Rochester

Local Institution, Stony Brook

Local Institution, Cincinnati

Local Institution, Cleveland

Local Institution, Oklahoma City

Local Institution, Philadelphia

Local Institution, Charleston

Local Institution, Memphis

Local Institution, Bellaire

Local Institution, Fort Worth

Local Institution, Houston

Local Institution, San Antonio

Local Institution, Herndon

Local Institution, Richmond

Local Institution, Kirkland

Local Institution, Spokane

Local Institution, Milwaukee

All Listed Sponsors
lead

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

NCT00110461 - Aripiprazole in Children and Adolescents With Bipolar I Disorder | Biotech Hunter | Biotech Hunter