Study of Erbitux™ (Cetuximab) in Pediatric Patients With Refractory Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

August 31, 2005

Primary Completion Date

March 31, 2008

Study Completion Date

March 31, 2008

Conditions
CancerRefractory Solid Tumor
Interventions
DRUG

Cetuximab + Irinotecan

Intravenous (IV) cetuximab 75 - 250 mg/m2 depending on dose escalation for MTD, weekly; irinotecan was administered at a dose of 16 or 20 mg/m2 or per dose escalation, administered x5 days x2 weeks, separated by 2 days off, every 21 days.

DRUG

Cetuximab + Irinotecan

Intravenous (IV) cetuximab 75 - 250 mg/m2 depending on dose escalation for MTD, weekly; irinotecan was administered at a dose of 20 mg/m2 or per dose escalation, administered x5 days x2 weeks, separated by 2 days off, every 21 days.

Trial Locations (9)

10021

Memorial Sloan Kettering Cancer Center, New York

21231

Sidney Kimmel Cancer Center At Johns Hopkins, Baltimore

30322

Children'S Healthcare Of Atlanta, Atlanta

32610

University Of Florida, Gainesville

37232

Vanderbilt University Medical Center Infectious Diseases, Nashville

77030

University Of Texas Md Anderson Cancer Ctr, Houston

80218

The Children'S Hospital, Denver

85016

Phoenix Children'S Hospital, Phoenix

85724

University Of Arizona Health Sciences Center, Tucson

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY

NCT00110357 - Study of Erbitux™ (Cetuximab) in Pediatric Patients With Refractory Solid Tumors | Biotech Hunter | Biotech Hunter