Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

PHASE3CompletedINTERVENTIONAL
Enrollment

823

Participants

Timeline

Start Date

June 30, 2005

Primary Completion Date

January 31, 2011

Study Completion Date

August 31, 2012

Conditions
Mucosal MelanomaRecurrent MelanomaStage IIIA Skin MelanomaStage IIIB Skin MelanomaStage IIIC Skin MelanomaStage IV Skin Melanoma
Interventions
DRUG

Carboplatin

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

OTHER

Pharmacological Study

Correlative studies

OTHER

Placebo

Given PO

DRUG

Sorafenib Tosylate

Given PO

Trial Locations (219)

2145

Sydney West Area Health Service-Westmead Hospital, Westmead

10016

Laura and Issac Perlmutter Cancer Center at NYU Langone, New York

10466

Montefiore Medical Center-Wakefield Campus, The Bronx

11794

Stony Brook University Medical Center, Stony Brook

12601

MidHudson Regional Hospital of Westchester Medical Center, Poughkeepsie

12801

Glens Falls Hospital, Glens Falls

13057

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

13210

State University of New York Upstate Medical University, Syracuse

14623

Interlakes Foundation Inc-Rochester, Rochester

14642

University of Rochester, Rochester

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15801

Oncology Hematology Associates of Northern Pennsylvania, DuBois

16801

Geisinger Medical Group, State College

17109

PinnacleHealth Cancer Center-Community Campus, Harrisburg

17405

WellSpan Health-York Hospital, York

17822

Geisinger Medical Center, Danville

18508

Hematology and Oncology Associates of North East Pennsylvania, Scranton

18510

Scranton Hematology Oncology, Scranton

19026

Delaware County Memorial Hospital, Drexel Hill

19047

Saint Mary Medical and Regional Cancer Center, Langhorne

19096

Lankenau Medical Center, Wynnewood

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Pennsylvania Hospital, Philadelphia

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19380

Chester County Hospital, West Chester

19390

Jennersville Regional Hospital, West Grove

19464

Pottstown Memorial Medical Center, Pottstown

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21701

Frederick Memorial Hospital, Frederick

22901

Martha Jefferson Hospital, Charlottesville

22908

University of Virginia Cancer Center, Charlottesville

23666

Virginia Oncology Associates-Hampton, Hampton

24541

Danville Regional Medical Center, Danville

25304

West Virginia University Charleston, Charleston

25701

Edwards Comprehensive Cancer Center, Huntington

25702

Saint Mary's Medical Center, Huntington

26506

West Virginia University Healthcare, Morgantown

27534

Wayne Memorial Hospital, Goldsboro

27710

Duke University Medical Center, Durham

27858

East Carolina University, Greenville

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina, Charleston

29506

McLeod Regional Medical Center, Florence

30033

Dekalb Medical Center, Decatur

30274

Southern Regional Medical Center, Riverdale

30309

Piedmont Hospital, Atlanta

30342

Atlanta Regional CCOP, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

31208

Medical Center of Central Georgia, Macon

31603

South Georgia Medical Center, Valdosta

31701

Phoebe Putney Memorial Hospital, Albany

32207

Baptist Cancer Institute, Jacksonville

32610

University of Florida, Gainesville

32803

Florida Hospital Orlando, Orlando

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33140

Mount Sinai Medical Center, Miami Beach

33308

Holy Cross Hospital, Fort Lauderdale

33316

Broward Health Medical Center, Fort Lauderdale

33458

Jupiter Medical Center, Jupiter

33612

Moffitt Cancer Center, Tampa

33805

Lakeland Regional Cancer Center, Lakeland

33901

Southwest Florida Regional Medical Center, Fort Meyers

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37403

Erlanger Medical Center, Chattanooga

37920

East Tennessee Baptist Hospital-Mercy Health Partners, Knoxville

39581

Singing River Hospital, Pascagoula

43015

Grady Memorial Hospital, Delaware

43055

Licking Memorial Hospital, Newark

43210

Ohio State University Comprehensive Cancer Center, Columbus

43215

Columbus CCOP, Columbus

Grant Medical Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

44106

Case Western Reserve University, Cleveland

44131

Cleveland Clinic Cancer Center Independence, Independence

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Akron City Hospital/Cooper Cancer Center, Akron

44691

Cleveland Clinic Wooster Specialty Center, Wooster

44708

Mercy Medical Center, Canton

44710

Aultman Health Foundation, Canton

45219

The Christ Hospital, Cincinnati

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45801

Saint Rita's Medical Center, Lima

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

46545

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46601

Memorial Hospital of South Bend, South Bend

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

47403

IU Health Bloomington, Bloomington

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48093

Saint John Macomb-Oakland Hospital, Warren

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48124

Oakwood Hospital and Medical Center, Dearborn

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Saint John Hospital and Medical Center, Detroit

48502

Hurley Medical Center, Flint

49007

West Michigan Cancer Center, Kalamazoo

49085

Oncology Care Associates PLLC, Saint Joseph

49503

Grand Rapids Clinical Oncology Program, Grand Rapids

49684

Munson Medical Center, Traverse City

50309

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Medical Oncology and Hematology Associates-Laurel, Des Moines

50701

Cedar Valley Medical Specialists, Waterloo

51503

Heartland Oncology and Hematology LLP, Council Bluffs

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52402

Physicians' Clinic of Iowa PC, Cedar Rapids

52403

Cedar Rapids Oncology Association, Cedar Rapids

52803

Genesis Medical Center - East Campus, Davenport

53121

Aurora Cancer Care-Southern Lakes, Elkhorn

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53717

Dean Hematology and Oncology Clinic, Madison

53792

University of Wisconsin Hospital and Clinics, Madison

54221

Holy Family Memorial Hospital, Manitowoc

54449

Marshfield Clinic, Marshfield

54601

Gundersen Lutheran Medical Center, La Crosse

54911

Fox Valley Hematology and Oncology, Appleton

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55125

Minnesota Oncology and Hematology PA-Woodbury, Woodbury

55379

Saint Francis Regional Medical Center, Shakopee

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

57104

Sanford Cancer Center-Oncology Clinic, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Medical Center-Fargo, Fargo

58201

Altru Cancer Center, Grand Forks

58501

Mid Dakota Clinic, Bismarck

59101

Montana Cancer Consortium NCORP, Billings

59102

Frontier Cancer Center and Blood Institute-Billings, Billings

60123

Advocate Sherman Hospital, Elgin

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60521

Hinsdale Hematology Oncology Associates Incorporated, Hinsdale

60625

Swedish Covenant Hospital, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61265

Trinity Medical Center, Moline

61801

Carle Cancer Center, Urbana

Carle Clinic-Urbana Main, Urbana

62526

Decatur Memorial Hospital, Decatur

62781

Memorial Medical Center, Springfield

63141

Center for Cancer Care and Research, St Louis

Mercy Hospital Saint Louis, St Louis

Saint Louis-Cape Girardeau CCOP, St Louis

64804

Freeman Health System, Joplin

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City CCOP, Prairie Village

66720

Cancer Center of Kansas - Chanute, Chanute

67152

Cancer Center of Kansas - Wellington, Wellington

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Main Office, Wichita

67401

Salina Regional Health Center, Salina

72205

University of Arkansas for Medical Sciences, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Cancer Care Associates, Oklahoma City

80012

The Medical Center of Aurora, Aurora

80113

Swedish Medical Center, Englewood

80124

Sky Ridge Medical Center, Lone Tree

80210

Porter Adventist Hospital, Denver

80218

Exempla Saint Joseph Hospital, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

80229

North Suburban Medical Center, Thornton

80301

Boulder Community Hospital, Boulder

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90033

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

92108

Kaiser Permanente-San Diego Mission, San Diego

92161

Veterans Administration-San Diego Medical Center, San Diego

92868

Saint Joseph Hospital - Orange, Orange

94063

Kaiser Permanente-Redwood City, Redwood City

94115

Kaiser Permanente-San Francisco, San Francisco

94118

California Pacific Medical Center-Pacific Campus, San Francisco

94304

Stanford Cancer Institute, Palo Alto

94589

Kaiser Permanente-Vallejo, Vallejo

94609

Bay Area Tumor Institute, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94904

Marin Cancer Care Inc, Greenbrae

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95405

Santa Rosa Memorial Hospital, Sana Rosa

95661

Kaiser Permanente-Roseville, Roseville

95825

Kaiser Permanente - Sacramento, Sacramento

96813

University of Hawaii Cancer Center, Honolulu

97213

Western Oncology Research Consortium, Portland

97227

Kaiser Permanente, Portland

98112

Group Health Cooperative-Seattle, Seattle

06102

Hartford Hospital, Hartford

06520

Yale University, New Haven

04240

Central Maine Medical Center, Lewiston

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

01605

Commonwealth Hematology Oncology PC-Worcester, Worcester

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

03756

Dartmouth Hitchcock Medical Center, Lebanon

07018-1095

Veterans Adminstration New Jersey Health Care System, East Orange

07601

Hackensack University Medical CCOP, Hackensack

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

02886

Kent County Hospital, Warwick

05405

University of Vermont College of Medicine, Burlington

98122-4307

Swedish Medical Center-First Hill, Seattle

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00110019 - Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery | Biotech Hunter | Biotech Hunter