79
Participants
Start Date
April 30, 2005
Primary Completion Date
November 30, 2010
Study Completion Date
November 30, 2014
filgrastim
As needed per physician discretion
cyclophosphamide
Cyclophosphamide Consolidation: 650 mg/m2; IV; days 1, 15, 29 Post-consolidation course 3: 650 mg/m2; IV; day 1
cytarabine
Induction 2: 3 g/m2; IV over 3 hrs; days 1-5 Consolidation: 75 mg/m2/d; IV push; days 2-5 and 16-19 Post-consolidation course 3: 75 mg/m2/d; IV push; days 3-6 and 10-13
daunorubicin
Induction: 60 mg/m2/d; IV; days 1, 2, and 3
dexamethasone
Induction 2: 0.1% QID; eye drops; days 1-6 Post consolidation course 2: 10 mg/m2/d; PO; days 1-28
doxorubicin
Post consolidation: 25 mg/m2; IV; days 1, 8, 15, and 22
leucovorin
For CNS during induction: 5 mg every 6 hrs for 4 doses; PO; days 1, 4, 8, 11, etx.; after methotrexate if WBC \< 3,000
mercaptopurine
Consolidation: 60 mg/m2; PO; days 1-28 Post-consolidation course 1: 60 mg/m2/d; PO; days 1-63 Post-consolidation course 4: 60 mg/m2/d; PO; daily for 2 yrs
methotrexate
Consolidation: 12 mg; intrathecal or intraventricularly; days 2, 9, 16, and 23 Post-consolidation course 1: 20 mg/m2/wk; PO; days 1, 8 15, 22, 29, 36, 43, 50, 57 Post-consolidation course 4: 20 mg/m2; PO; weekly for 2 yrs
mitoxantrone
Induction 2: 80 mg/m2; IV; day 3
Asparaginase
Induction: 2,000 IU/m2; IM or IV; day 15
prednisone
Induction: 60 mg/m2/d; PO or IV; days 1-35
thioguanine
Post-consolidation course 3: 60 mg/m2/d; PO; days 1-14
vincristine
Induction: 1.4 mg/m2/d (2 mg max); IV; days 1, 8, 15, 22
radiation therapy
For CNS during consolidation: cranial radiation after blasts are no longer present in spinal fluid. Total dose of 1800 cGy over 2 wks in 10 fractions of 180 cGy 5 days/wk.
allopurinol
300 mg/d PO Days 1-7
bactrim
1 double strenth tablet 2x/d, 2x/wk, PO, begin with prednisone
Wayne Memorial Hospital, Incorporated, Goldsboro
Rutherford Hospital, Rutherfordton
CCOP - Upstate Carolina, Spartanburg
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg
Hollings Cancer Center at Medical University of South Carolina, Charleston
McLeod Regional Medical Center, Florence
AnMed Cancer Center, Anderson
Cleveland Clinic Taussig Cancer Center, Cleveland
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
CCOP - Montana Cancer Consortium, Billings
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings
Northern Rockies Radiation Oncology Center, Billings
St. Vincent Healthcare Cancer Care Services, Billings
Frontier Cancer Center, Great Falls
Great Falls Clinic - Main Facility, Great Falls
Sletten Cancer Institute at Benefis Healthcare, Great Falls
Northern Montana Hospital, Havre
St. Peter's Hospital, Helena
St. James Healthcare Cancer Care, Butte
Bozeman Deaconess Cancer Center, Bozeman
Community Medical Center, Missoula
Guardian Oncology and Center for Wellness, Missoula
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula
Glacier Oncology, PLLC, Kalispell
Kalispell Medical Oncology at KRMC, Kalispell
Kalispell Regional Medical Center, Kalispell
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Independence Regional Health Center, Independence
Liberty Hospital, Liberty
Saint Luke's East - Lee's Summit, Lee's Summit
Truman Medical Center - Hospital Hill, Kansas City
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City
St. Joseph Medical Center, Kansas City
North Kansas City Hospital, Kansas City
Parvin Radiation Oncology, Kansas City
CCOP - Kansas City, Kansas City
Research Medical Center, Kansas City
Heartland Regional Medical Center, Saint Joseph
Lawrence Memorial Hospital, Lawrence
Shawnee Mission Medical Center, Shawnee Mission
Menorah Medical Center, Overland Park
Cancer Center of Kansas, PA - Chanute, Chanute
Cancer Center of Kansas, PA - El Dorado, El Dorado
Cancer Center of Kansas, PA - Salina, Salina
Cancer Center of Kansas, PA - Kingman, Kingman
Cancer Center of Kansas, PA - Newton, Newton
Cancer Center of Kansas, PA - Pratt, Pratt
Cancer Center of Kansas, PA - Wellington, Wellington
Cancer Center of Kansas, PA - Winfield, Winfield
Associates in Womens Health, PA - North Review, Wichita
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita
Cancer Center of Kansas, PA - Wichita, Wichita
CCOP - Wichita, Wichita
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita
Wesley Medical Center, Wichita
Cancer Center of Kansas-Independence, Independence
Cancer Center of Kansas, PA - Parsons, Parsons
Cancer Center of Kansas, PA - Dodge City, Dodge City
Southwest Medical Center, Liberal
Rocky Mountain Oncology, Casper
Welch Cancer Center at Sheridan Memorial Hospital, Sheridan
Huntsman Cancer Institute at University of Utah, Salt Lake City
Providence Saint Joseph Medical Center - Burbank, Burbank
Fred Hutchinson Cancer Research Center, Seattle
Harborview Medical Center, Seattle
Minor and James Medical, PLLC, Seattle
Group Health Central Hospital, Seattle
Polyclinic First Hill, Seattle
St. Joseph Cancer Center, Bellingham
Olympic Hematology and Oncology, Bremerton
Cancer Care Northwest - Spokane South, Spokane
Columbia Basin Hematology, Kennewick
University of Michigan Comprehensive Cancer Center, Ann Arbor
Billings Clinic - Downtown, Billings
Big Sky Oncology, Great Falls
Montana Cancer Specialists at Montana Cancer Center, Missoula
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle
University Cancer Center at University of Washington Medical Center, Seattle
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK