A Study to Assess the Safety and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

673

Participants

Timeline

Start Date

July 31, 2005

Primary Completion Date

December 31, 2007

Study Completion Date

December 31, 2007

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Methotrexate

7.5-20mg po weekly

DRUG

tocilizumab [RoActemra/Actemra]

8mg/kg iv every 4 weeks

Trial Locations (147)

11

Lima

13

Lima

1000

Ljubljana

1862

Diepkloof

2000

Maribor

2040

Radiokop

2050

Sydney

2400

Copenhagen

2609

Lillehammer

2650

Hvidovre

3400

Hillerød

4001

Cape Town

4102

Woolloongabba

5011

Woodville

5041

Adelaide

6008

Shenton Park

7000

Hobart

7405

Pinelands

7500

Cape Town

7600

Levanger

11000

Belgrade

12206

Albany

13210

Syracuse

14004

Córdoba

14050

Mexico City

15706

Santiago de Compostela

16132

Genova

16635

Duncansville

18250

Niška Banja

19002

Guadalajara

19090

Willow Grove

19152

Philadelphia

19610

Wyomissing

20157

Milan

20770

Greenbelt

23320

Chesapeake

27004

Lugo

27100

Pavia

28304

Fayetteville

28602

Hickory Grove

28922

Alcorcón

29204

Columbia

29406

Charleston

29601

Greenville

29609

Brest

31048

Haifa

32127

Port Orange

33458

Jupiter

33609

Tampa

33614

Tampa

34354

Haifa

34684

Palm Habor

Palm Harbor

35144

Panevezys

36111

Montgomery

37007

Salamanca

37203

Nashville

37343

Hixson

38320

San Cristóbal de La Laguna

38802

Tupelo

39232

Flowood

42100

Reggio Emilia

42102

Bowling Green

44143

Mayfield

44281

Kfar Saba

44340

Guadalajara

44620

Guadalajara

44718

Canton

45235

Guadalajara

46017

Valencia

46202

Indianapolis

48910

Lansing

49048

Kalamazoo

49546

Grand Rapids

50009

Kaunas

50322

Des Moines

52401

Cedar Rapids

52621

Ramat Gan

53100

Siena

55121

Eagan

56303

Saint Cloud

60053

Morton Grove

62704

Springfield

63117

St Louis

63131

St Louis

69437

Lyon

70300

Rishon LeZiyyon

70458

Slidell

70808

Baton Rouge

72205

Little Rock

73103

Oklahoma City

73109

Oklahoma City

74104

Tulsa

74135

Tulsa

75150

Mesquite

75679

Paris

76031

Rouen

76231

Šiauliai

78306

Ashkelon

78705

Austin

79124

Amarillo

83404

Idaho Falls

83642

Meridian

85013

Phoenix

85208

Mesa

85253

Paradise Valley

90045

Los Angeles

90806

Long Beach

92262

Palm Springs

92288

Klaipėda

92646

Huntington Beach

93454

Santa Maria

94578

San Leandro

95825

Sacramento

98043

Mountlake Terrace

98502

Olympia

98902

Yakima

99204

Spokane

230022

Hefei Anhui

250012

Jinan

510630

Guangzhou

8410101

Beersheba

01201

Pittsfield

03820

Dover

03060

Nashua

08035

Haddon Heights

Barcelona

08903

New Brunswick

C1015ABO

Buenos Aires

C1428DQG

Buenos Aires

S2000PBJ

Rosario

B1878DVB

San Juan Bautista

V8V 3P9

Victoria

R3A 1M3

Winnipeg

R3A 1M4

Winnipeg

A1A 5E8

St. John's

L7M 4Y1

Burlington

L8N 2B6

Hamilton

N2M 5N6

Kitchener

L5M 2V8

Mississauga

K1H 1A2

Ottawa

LT-08661

Vilnius

06700

Mexico City

07760

Mexico City

2801-951

Almada

1050-34

Lisbon

1349-019

Lisbon

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT00109408 - A Study to Assess the Safety and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter