NCT00106548View on ClinicalTrials.gov

A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

623

Participants

Timeline

Start Date

Not specified

Study Completion Date

October 31, 2007

Conditions
Rheumatoid Arthritis
Interventions
DRUG

tocilizumab [RoActemra/Actemra]

4mg/kg iv / month

DRUG

tocilizumab [RoActemra/Actemra]

8mg/kg iv / month

DRUG

Placebo

iv / month

DRUG

Methotrexate

10-25mg/week

Trial Locations (74)

852

Hong Kong

1011

Lausanne

1023

Budapest

1090

Vienna

1100

Vienna

1130

Vienna

1160

Vienna

1405

Buenos Aires

1606

Sofia

1784

Sofia

3010

Bern

4004

Debrecen

4184

Douglas

4558

Maroochydore

5041

Adelaide

6008

Shenton Park

7632

Pécs

9007

Sankt Gallen

9010

Varna

10400

Bangkok

10700

Bangkok

14059

Berlin

14080

Mexico City

24576

Bad Bramstedt

25030

Besançon

31000

Chihuahua City

31048

Haifa

31096

Haifa

33100

Udine

34295

Montpellier

44100

Ferrara

44620

Guadalajara

44690

Guadalajara

49100

Petah Tikva

50200

Chiang Mai

50924

Cologne

53100

Siena

61231

Bad Nauheim

64239

Tel Aviv

69120

Heidelberg

72000

Le Mans

72076

Tübingen

75010

Paris

75012

Paris

75014

Paris

76530

Baden-Baden

78240

San Luis Potosí City

84101

Beersheba

90127

Palermo

91056

Erlangen

91120

Jerusalem

94010

Créteil

98125

Gazzi

119074

Singapore

258499

Singapore

C1015ABO

Buenos Aires

C1428CQG

Buenos Aires

91350-200

Porto Alegre

05651-901

São Paulo

T2N 4N1

Calgary

V5Z 1L7

Vancouver

V8V 3P9

Victoria

R3A 1M3

Winnipeg

A1B 3E1

St. John's

L7M 4Y1

Burlington

L3Y 3R7

Newmarket

K1H 1A2

Ottawa

M4N 3M5

Toronto

H1T 4B3

Montreal

H2L 1S6

Montreal

G1W 4R4

Sainte-Foy

Unknown

Hong Kong

07760

Mexico City

921 01

Piešťany

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY