A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

499

Participants

Timeline

Start Date

May 31, 2005

Primary Completion Date

November 30, 2007

Study Completion Date

November 30, 2007

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Methotrexate

10-25mg weekly

DRUG

Placebo

iv every 4 weeks

DRUG

tocilizumab [RoActemra/Actemra]

8mg/kg iv every 4 weeks

DRUG

tocilizumab [RoActemra/Actemra]

4mg/kg iv every 4 weeks

Trial Locations (168)

108

Reykjavik

1011

Lausanne

2050

Sydney

2170

Merksem

3144

Malvern

3500

Hasselt

4102

Woolloongabba

6008

Shenton Park

9300

Aalst

10003

New York

10021

New York

10117

Berlin

11020

Great Neck

12206

Albany

13790

Johnson City

13905

Binghamton

14127

Orchard Park

14618

Rochester

16635

Duncansville

17822

Danville

19004

Bala-Cynwyd

19140

Philadelphia

19152

Philadelphia

20122

Milan

20157

Milan

20902

Wheaton

21201

Baltimore

21205

Baltimore

23298

Richmond

23502

Norfolk

24153

Salem

25123

Brescia

27100

Pavia

28210

Charlotte

28401

Wilmington

28602

Hickory Grove

28801

Asheville

30342

Atlanta

31054

Toulouse

32778

Tavares

33076

Bordeaux

33100

Udine

33180

Aventura

33334

Fort Lauderdale

33407

West Palm Beach

33486

Boca Raton

33540

Zephyrhills

33614

Tampa

34239

Sarasota

34684

Palm Habor

35128

Padua

35294

Birmingham

35801

Huntsville

38305

Jackson

38802

Tupelo

39245

Gommern

40202

Louisville

40515

Lexington

42102

Bowling Green

42701

Elizabethtown

44620

Guadalajara

44652

Herne

44718

Canton

45219

Cincinnati

48910

Lansing

50924

Cologne

53217

Glendale

55805

Duluth

55905

Rochester

56100

Pisa

58501

Bismarck

59037

Lille

59802

Missoula

60611

Chicago

62703

Springfield

62704

Springfield

63110

St Louis

63128

St Louis

63131

St Louis

63141

St Louis

65185

Karlstad

65191

Wiesbaden

67098

Strasbourg

69437

Lyon

70121

New Orleans

71913

Hot Springs

72205

Little Rock

73103

Oklahoma City

74104

Tulsa

74135

Tulsa

75231

Dallas

75475

Paris

75679

Paris

77074

Houston

78705

Austin

80045

Willow Grove

80054

Amiens

80910

Colorado Springs

81541

München

83642

Meridian

83702

Boise

84403

Ogden

85251

Scottsdale

85258

Scottsdale

85724

Tucson

89119

Las Vegas

90095

Los Angeles

90505

Torrance

90806

Long Beach

90808

Long Beach

92101

San Diego

92108

San Diego

92260

Palm Desert

92801

Anaheim

92835

Fullerton

93454

Santa Maria

94275

Le Kremlin-Bicêtre

97080

Würzburg

97401

Eugene

98104

Seattle

98195

Seattle

46202-5100

Indianapolis

04102

Portland

01107

Springfield

01605

Worcester

59107-5100

Billings

08055

Medford

08619

Mercerville

07666

Teaneck

27599-7280

Chapel Hill

75231-4406

Dallas

T2V 1P9

Calgary

T5H 3V9

Edmonton

R3A 1M3

Winnipeg

L7M 4Y1

Burlington

N2M 5N6

Kitchener

N6A 4V2

London

L5M 2V8

Mississauga

L3Y 3R7

Newmarket

M5T 3L9

Toronto

H2L 1S6

Montreal

06202

Nice

01067

Dresden

7511 JX

Enschede

6525 GA

Nijmegen

00716

Ponce

551 85

Jönköping

205 02

Malmo

171 76

Stockholm

RG24 9NA

Basingstoke

BA1 1RL

Bath

B29 6JD

Birmingham

WS11 5XY

Cannock

DE22 3NE

Derby

LA1 4RP

Lancaster

LS1 3EX

Leeds

L9 7AL

Liverpool

SE1 9RT

London

SE5 9PJ

London

M13 9WL

Manchester

M41 5SL

Manchester

TS4 3BW

Middlesbrough

NE1 4LP

Newcastle upon Tyne

NR4 7UY

Norwich

OX3 7LD

Oxford

M6 8HD

Salford

SO16 6YD

Southampton

ST6 7AG

Stoke-on-Trent

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT00106522 - A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy | Biotech Hunter | Biotech Hunter