103
Participants
Start Date
April 30, 2005
Primary Completion Date
August 31, 2011
Study Completion Date
August 31, 2011
Comparator: MK0752, Notch Inhibitor
Dose escalating beginning with rising dose levels of 300, 450, and 600 mg/day in a continuous dosing schedule.
Comparator: MK0752, Notch Inhibitor - 450 mg
Dose 450 mg capsules daily for 28 day cycles.
Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off
Dose escalating in a repeating intermittent dosing schedule of 3 days on and 4 days off at rising dose levels of 450, 600, 800, 1000, 1200, and 1400 mg/day.
Comparator: MK0752, Notch Inhibitor - 1 day on, 6 off
Dose escalating in a repeating intermittent dosing schedule of 1 day on/6 days off at rising dose levels of 600, 900, 1200, 1500, 1800, 2400, 3200 mg/day once weekly and then increase at 33% increments.
Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off 350 mg
Dose 350 mg capsules daily intermittent 3 days on/4 days off dosing. THIS DOSING SCHEDULE IS NO LONGER UNDER INVESTIGATION
Merck Sharp & Dohme LLC
INDUSTRY