Bortezomib in Treating Patients With Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

December 31, 2004

Primary Completion Date

May 31, 2010

Study Completion Date

April 30, 2014

Conditions
Insular Thyroid CancerRecurrent Thyroid CancerStage II Follicular Thyroid CancerStage II Papillary Thyroid CancerStage IV Follicular Thyroid CancerStage IV Papillary Thyroid Cancer
Interventions
DRUG

Bortezomib

Administered IV at the dose of 1.3 mg/m\^2 on a twice-weekly schedule for 2 consecutive weeks on days 1, 4, 8, and 11, followed by a 10 day rest period on days 12-21 (one cycle). In the absence of clinical progression, treatment continued for a minimum of 4 treatment cycles (or 12 weeks).

Trial Locations (9)

20057

Lombardi Comprehensive Cancer Center at Georgetown University, Washington D.C.

30322

Emory University, Atlanta

43210

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

44195

Cleveland Clinic Foundation, Cleveland

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland

77030

M D Anderson Cancer Center, Houston

80045

University of Colorado at Denver Health Sciences Center, Aurora

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Harvard Cancer Center, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00104871 - Bortezomib in Treating Patients With Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy | Biotech Hunter | Biotech Hunter