Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

February 28, 2005

Primary Completion Date

April 30, 2011

Study Completion Date

April 30, 2011

Conditions
Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions
DRUG

L-asparaginase

Given IM

DRUG

doxorubicin hydrochloride

Given IV

DRUG

therapeutic hydrocortisone

40 mg/m2/day PO divided BID or TID

DRUG

vincristine sulfate

Given IV

BIOLOGICAL

epratuzumab

Given IV

DRUG

cytarabine

Given IT

DRUG

prednisone

Given orally

DRUG

pegaspargase

Given IM

DRUG

dexrazoxane hydrochloride

Given IV

DRUG

methotrexate

Given IT

DRUG

etoposide

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

leucovorin calcium

Given IV

BIOLOGICAL

filgrastim

Given SC

Trial Locations (46)

2145

The Children's Hospital at Westmead, Sydney

6008

Princess Margaret Hospital for Children, Perth

10016

New York University Langone Medical Center, New York

10032

Columbia University Medical Center, New York

14642

University of Rochester, Rochester

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

29425

Medical University of South Carolina, Charleston

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

33607

Saint Joseph Children's Hospital of Tampa, Tampa

35294

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt-Ingram Cancer Center, Nashville

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky, Lexington

43205

Nationwide Children's Hospital, Columbus

46202

Indiana University Medical Center, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48202

Wayne State University, Detroit

53226

Midwest Children's Cancer Center, Milwaukee

55455

University of Minnesota Medical Center-Fairview, Minneapolis

55905

Mayo Clinic, Rochester

64108

The Childrens Mercy Hospital, Kansas City

70112

Tulane University Health Sciences Center, New Orleans

77030

Baylor College of Medicine, Houston

M D Anderson Cancer Center, Houston

80045

Children's Hospital Colorado, Aurora

84113

Primary Children's Medical Center, Salt Lake City

87106

University of New Mexico Cancer Center, Albuquerque

90027

Children's Hospital Los Angeles, Los Angeles

90095

David Geffen School of Medicine at UCLA, Los Angeles

90806

Miller Children's Hospital, Long Beach

92354

Loma Linda University Medical Center, Loma Linda

94143

University of California San Francisco Medical Center-Parnassus, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

93636-8762

Children's Hospital Central California, Madera

92868-3874

Childrens Hospital of Orange County, Orange

04401

Eastern Maine Medical Center, Bangor

21287-8936

Johns Hopkins University, Baltimore

02115

Dana-Farber Cancer Institute, Boston

08903

UMDNJ - Robert Wood Johnson University Hospital, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

H3T 1C5

Hospital Sainte-Justine, Montreal

00912

San Jorge Children's Hospital, Santurce

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00098839 - Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL) | Biotech Hunter | Biotech Hunter