Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

October 31, 2004

Primary Completion Date

January 31, 2010

Study Completion Date

September 30, 2014

Conditions
Lymphoma
Interventions
BIOLOGICAL

filgrastim

5 mcg/kg subQ injection daily Day 14 until ANC \> or = 500 uL for 2 days or 1500 uL for 1 day (Cycle 6)

BIOLOGICAL

rituximab

375 mg/sq m IV infusion (max rate of 400 mg/hr) on Days 3, 10, 17, \& 24 of Cycle 1 nad Days 3 \& 10 of Cycle 2

DRUG

cytarabine

2 g/sq m IV infusion over 2 hours q 12 hrs x 8 doses Days 1-4 of Cycle 6

DRUG

etoposide

5 mg/kg IV infusion over 12 hrs q 12 hrs x 8 doses Days 1-4 of Cycle 6

DRUG

leucovorin calcium

100 mg/sq m IV infusion q 6 hrs starting 24 hrs after ea MTX dose until serum MTX \< or = 0.05uM Cycles 1-5.

DRUG

methotrexate

8 g/sq m IV infusion over 4 hrs Days 1 \& 15 Cycles 1, 2, \& 3; Day 15 Cycle 4 and Day 1 Cycle 5.

DRUG

temozolomide

150 mg/sq m PO Days 7-11 Cycles 1-5.

Trial Locations (30)

13210

SUNY Upstate Medical University Hospital, Syracuse

19713

CCOP - Christiana Care Health Services, Newark

19958

Tunnell Cancer Center at Beebe Medical Center, Lewes

21921

Union Hospital Cancer Program at Union Hospital, Elkton MD

24541

Danville Regional Medical Center, Danville

46845

Fort Wayne Medical Oncology and Hematology, Fort Wayne

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

64068

Liberty Hospital, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64108

Truman Medical Center - Hospital Hill, Kansas City

64111

Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City

64114

St. Joseph Medical Center, Kansas City

64116

North Kansas City Hospital, Kansas City

Parvin Radiation Oncology, Kansas City

64131

CCOP - Kansas City, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

66204

Shawnee Mission Medical Center, Shawnee Mission

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's Hospital - South, Overland Park

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

60637-1470

University of Chicago Cancer Research Center, Chicago

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

11794-9446

Stony Brook University Cancer Center, Stony Brook

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus

02903

Rhode Island Hospital Comprehensive Cancer Center, Providence

02906

Miriam Hospital, Providence

05602

Mountainview Medical, Berlin Corners

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT00098774 - Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Primary CNS Lymphoma | Biotech Hunter | Biotech Hunter