168
Participants
Start Date
November 30, 2004
Primary Completion Date
September 30, 2013
filgrastim
given subcutaneously (SC)
cyclophosphamide
IV over 15-30 minutes
cytarabine
IV over 3 hours twice daily
daunorubicin hydrochloride
IV over 15 minutes
dexamethasone
oral twice daily
etoposide
IV over 1 hour
leucovorin calcium
rescue IV over 24 hours
mercaptopurine
oral
methotrexate
intramuscularly (IM)
pegaspargase
intramuscularly (IM)
therapeutic hydrocortisone
vincristine sulfate
given IV
radiation therapy
Patients with isolated testicular relapse will start Induction with a single dose of high-dose methotrexate (HDMTX) and will not receive either testicular or cranial radiation. Patients with isolated CNS relapse will NOT receive the initial dose of HDMTX prior to Induction, but will receive 1200 cGy of cranial radiation after completing the initial 12 months of intensive systemic chemotherapy.
Starship Children's Health, Auckland
Swiss Pediatric Oncology Group Lausanne, Lausanne
Swiss Pediatric Oncology Group Geneva, Geneva
Swiss Pediatric Oncology Group Bern, Bern
Princess Margaret Hospital for Children, Perth
Christchurch Hospital, Christchurch
NYU Cancer Institute at New York University Medical Center, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx
New York Medical College, Valhalla
Schneider Children's Hospital, New Hyde Park
Maimonides Cancer Center at Maimonides Medical Center, Brooklyn
Winthrop University Hospital, Mineola
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Alfred I. duPont Hospital for Children, Wilmington
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke
West Virginia University Health Sciences Center - Charleston, Charleston
Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown
Duke Comprehensive Cancer Center, Durham
Hollings Cancer Center at Medical University of South Carolina, Charleston
Greenville Hospital Cancer Center, Greenville
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
M.D. Anderson Cancer Center at Orlando, Orlando
Nemours Children's Clinic - Orlando, Orlando
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami
Miami Children's Hospital, Miami
Baptist-South Miami Regional Cancer Program, Miami
Broward General Medical Center Cancer Center, Fort Lauderdale
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
UAB Comprehensive Cancer Center, Birmingham
T.C. Thompson Children's Hospital, Chattanooga
East Tennessee Children's Hospital, Knoxville
Kosair Children's Hospital, Louisville
Medical University of Ohio Cancer Center, Toledo
Cleveland Clinic Taussig Cancer Center, Cleveland
Tod Children's Hospital, Youngstown
St. Vincent Indianapolis Hospital, Indianapolis
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Hurley Medical Center, Flint
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Blank Children's Hospital, Des Moines
Midwest Children's Cancer Center at Children's Hospital of Wisconsin, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Gundersen Lutheran Center for Cancer and Blood, La Crosse
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
Mayo Clinic Cancer Center, Rochester
CCOP - MeritCare Hospital, Fargo
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Keyser Family Cancer Center at Advocate Hope Children's Hospital, Oak Lawn
Children's Mercy Hospital, Kansas City
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Cancer Institute, Oklahoma City
Medical City Dallas Hospital, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo
Children's Hospital Center for Cancer and Blood Disorders, Aurora
Presbyterian - St. Luke's Medical Center, Denver
Southern California Permanente Medical Group, Downey
Childrens Hospital Los Angeles, Los Angeles
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Children's Hospital and Research Center Oakland, Oakland
Lucile Packard Children's Hospital at Stanford University Medical Center, Palo Alto
Sutter Cancer Center, Sacramento
Kaiser Permanente Medical Center - Oakland, Sacramento
Cancer Research Center of Hawaii, Honolulu
Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland
Phoenix Children's Hospital, Phoenix
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson
City of Hope Comprehensive Cancer Center, Duarte
Jonsson Comprehensive Cancer Center at UCLA, Los Angeles
Children's Hospital Central California, Madera
Connecticut Children's Medical Center, Hartford
Children's National Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise
University of Illinois Cancer Center, Chicago
Advocate Lutheran General Cancer Care Center, Park Ridge
Simmons Cooper Cancer Institute, Springfield
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City
Lucille P. Markey Cancer Center at University of Kentucky, Lexington
CancerCare of Maine at Eastern Maine Medical Center, Bangor
Floating Hospital for Children at Tufts - New England Medical Center, Boston
C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Butterworth Hospital at Spectrum Health, Grand Rapids
CCOP - Kalamazoo, Kalamazoo
University of Mississippi Cancer Clinic, Jackson
CCOP - Nevada Cancer Research Foundation, Las Vegas
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Hackensack University Medical Center Cancer Center, Hackensack
Overlook Hospital, Morristown
Saint Peter's University Hospital, New Brunswick
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
University of New Mexico Cancer Center, Albuquerque
Brooklyn Hospital Center, Brooklyn
Roswell Park Cancer Institute, Buffalo
Stony Brook University Cancer Center, Stony Brook
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Wake Forest University Comprehensive Cancer Center, Winston-Salem
Akron Children's Hospital, Akron
Rainbow Babies and Children's Hospital, Cleveland
Nationwide Children's Hospital, Columbus
Dayton Children's - Dayton, Dayton
Knight Cancer Institute at Oregon Health and Science University, Portland
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
St. Christopher's Hospital for Children, Philadelphia
Rhode Island Hospital Comprehensive Cancer Center, Providence
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
Vanderbilt-Ingram Cancer Center, Nashville
Baylor University Medical Center - Houston, Houston
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
Fletcher Allen Health Care - University Health Center Campus, Burlington
Inova Fairfax Hospital, Falls Church
Providence Cancer Center at Sacred Heart Medical Center, Spokane
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Alberta Hospital, Edmonton
Children's & Women's Hospital of British Columbia, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Children's Health and Rehabilitation Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston
Children's Hospital of Eastern Ontario, Ottawa
Hopital Sainte Justine, Montreal
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon
Centre Hospitalier Universitaire de Quebec, Québec
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK