Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

October 31, 2004

Primary Completion Date

July 31, 2010

Study Completion Date

July 31, 2010

Conditions
Recurrent Childhood Anaplastic AstrocytomaRecurrent Childhood Brain Stem GliomaRecurrent Childhood EpendymomaRecurrent Childhood Giant Cell GlioblastomaRecurrent Childhood GlioblastomaRecurrent Childhood GliosarcomaRecurrent Childhood MedulloblastomaRecurrent Childhood Oligodendroglioma
Interventions
DRUG

lapatinib ditosylate

Given orally

PROCEDURE

therapeutic conventional surgery

Undergo surgery

OTHER

laboratory biomarker analysis

Correlative studies

OTHER

pharmacological study

Correlative studies

PROCEDURE

positron emission tomography

Correlative studies

PROCEDURE

magnetic resonance imaging

Correlative studies

Trial Locations (1)

38105

Pediatric Brain Tumor Consortium, Memphis

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT00095940 - Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors | Biotech Hunter | Biotech Hunter